Hypernil is a prescription antihypertensive medication formulated with the active ingredient amlodipine besylate, a calcium channel blocker. It is clinically designed to manage hypertension and chronic angina by relaxing blood vessels, thereby improving blood flow and reducing cardiac workload. This medication offers a reliable, once-daily dosing regimen suitable for long-term cardiovascular management under medical supervision. Hypernil is trusted by healthcare professionals for its efficacy in supporting stable blood pressure levels and enhancing patient quality of life.

Features

• Contains amlodipine besylate 5 mg or 10 mg per tablet
• Once-daily oral administration
• Extended-release formulation for 24-hour coverage
• Manufactured under cGMP (current Good Manufacturing Practices)
• Available in blister packs of 30 tablets
• Vegan-friendly and lactose-free excipients

Benefits

• Effectively lowers systolic and diastolic blood pressure
• Reduces frequency of angina episodes
• Minimizes risk of stroke, heart attack, and kidney damage associated with hypertension
• Supports consistent daily activity without significant drowsiness
• Promotes vascular health through smooth muscle relaxation
• Compatible with long-term use under medical guidance

Common use

Hypernil is primarily indicated for the management of hypertension (high blood pressure) in adults. It may be used as monotherapy or in combination with other antihypertensive agents. Additionally, it is prescribed for the treatment of chronic stable angina and vasospastic (Prinzmetal’s) angina. Its mechanism of action involves selective inhibition of calcium ion influx across cardiac and vascular smooth muscle cells, resulting in peripheral arterial vasodilation and reduced afterload.

Dosage and direction

The recommended initial dose for hypertension or angina is 5 mg once daily. Dosage may be increased to a maximum of 10 mg once daily based on individual patient response and tolerability. Hypernil may be taken with or without food. Tablets should be swallowed whole with a glass of water; do not crush or chew. Dosage adjustments are necessary for patients with hepatic impairment or elderly patients. Always follow the prescribing physician’s instructions.

Precautions

• Regular monitoring of blood pressure and heart rate is advised.
• Use with caution in patients with heart failure or severe aortic stenosis.
• May cause peripheral edema; report sudden weight gain or swelling to a physician.
• Avoid abrupt discontinuation to prevent rebound hypertension.
• Not recommended during pregnancy unless clearly needed.
• Caution advised when operating machinery until response is known.

Contraindications

Hypernil is contraindicated in patients with known hypersensitivity to amlodipine or any component of the formulation. It should not be used in patients with severe hypotension (systolic BP <90 mmHg) or cardiogenic shock. Concomitant use with strong CYP3A4 inducers or inhibitors may require alternative therapy.

Possible side effects

Common side effects may include peripheral edema, dizziness, flushing, palpitations, and headache. Less frequently reported effects include nausea, fatigue, abdominal pain, and somnolence. Rare but serious side effects include symptomatic hypotension, worsening angina, myocardial infarction, and arrhythmias. Patients should seek medical attention if they experience signs of allergic reaction, such as rash, itching, or swelling.

Drug interaction

Hypernil may interact with:

• Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) — may increase amlodipine levels
• Simvastatin — increased risk of myopathy
• Other antihypertensive agents — additive hypotensive effects
• Sildenafil and other PDE5 inhibitors — may enhance hypotensive effects
• Cyclosporine — may increase cyclosporine concentrations

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule. Consult a healthcare provider if multiple doses are missed.

Overdose

Overdose may lead to pronounced hypotension and reflex tachycardia. In cases of suspected overdose, seek immediate medical attention. symptomatic and supportive measures should be instituted, including elevation of extremities and administration of vasopressors under clinical supervision. Hemodialysis is not likely to be effective due to high protein binding.

Storage

Store at room temperature (15–30°C) in the original container, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider before starting or changing any medication. Individual response to Hypernil may vary. Only a qualified physician can determine the appropriate treatment based on medical history and current health status.

Reviews

“Hypernil has provided consistent BP control with minimal side effects. My patients appreciate the once-daily convenience.” — Dr. Elena Rostova, Cardiologist
“After struggling with multiple medications, Hypernil finally stabilized my blood pressure. I’ve had no significant dizziness.” — Marcus T., 58
“Effective for angina management. I’ve been able to resume light exercise without chest pain.” — Linda G., 64