Zanaflex (tizanidine hydrochloride) is a short-acting muscle relaxant indicated for the management of spasticity. It is a centrally acting alpha-2 adrenergic agonist that works by blocking nerve impulses (pain sensations) that are sent to the brain, thereby reducing muscle tone and the frequency of painful muscle spasms. It is commonly prescribed for conditions such as multiple sclerosis, spinal cord injury, and other neurological disorders that cause increased muscle tone. Proper medical supervision is essential for safe and effective use.

Features

• Active ingredient: Tizanidine hydrochloride
• Available in 2 mg and 4 mg tablet strengths, and as a capsule
• Short-acting formulation with rapid onset of effect
• Prescription-only medication (Rx)
• Manufactured under strict pharmaceutical quality standards

Benefits

• Effectively reduces muscle spasticity and associated discomfort
• Improves range of motion and voluntary motor function
• May enhance ability to perform daily activities and participate in physical therapy
• Can contribute to improved sleep by alleviating nighttime muscle spasms
• Short half-life allows for flexible dosing relative to need
• Non-sedating at therapeutic doses for many patients when used as directed

Common use

Zanaflex is primarily used to manage spasticity resulting from multiple sclerosis, spinal cord injuries, and other neurological conditions. It is often incorporated into a broader therapeutic regimen that may include physical therapy, occupational therapy, and other medications. It is not intended for use as an analgesic or anti-inflammatory agent.

Dosage and direction

Dosage must be individualized based on patient response and tolerability. The recommended starting dose is 2 mg, increased gradually in 2–4 mg increments, with doses spaced 6–8 hours apart. The total daily dose should not exceed 36 mg. Tablets can be taken with or without food, but consistency in administration relative to meals is advised due to food effect on absorption. Capsules should be swallowed whole. Always follow the specific dosing instructions provided by the prescribing healthcare professional.

Precautions

Use with caution in patients with renal or hepatic impairment, as tizanidine is extensively metabolized. Blood pressure should be monitored, especially during dose titration. Zanaflex may cause sedation and dizziness; patients should avoid driving or operating machinery until they know how the medication affects them. Alcohol and other CNS depressants should be avoided. Abrupt discontinuation should be avoided; taper dose gradually under medical supervision.

Contraindications

Zanaflex is contraindicated in patients with known hypersensitivity to tizanidine or any component of the formulation. Concomitant use with potent CYP1A2 inhibitors such as fluvoxamine or ciprofloxacin is contraindicated due to significantly increased tizanidine plasma levels and risk of adverse effects.

Possible side effects

Common side effects may include dry mouth, somnolence, asthenia (weakness), dizziness, and hypotension. Less frequently, hallucinations, elevated liver enzymes, or bradycardia may occur. Most side effects are dose-dependent. Patients should report any persistent or severe side effects to their healthcare provider.

Drug interaction

Tizanidine is primarily metabolized by CYP1A2. Concomitant use with CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin) is contraindicated. Use with other alpha-2 adrenergic agonists may enhance hypotensive and sedative effects. CNS depressants (alcohol, benzodiazepines, opioids) may potentiate sedation. Oral contraceptives may reduce tizanidine clearance. Always inform your healthcare provider of all medications you are taking.

Missed dose

If a dose is missed, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule.

Overdose

Symptoms of overdose may include severe dizziness, somnolence, vomiting, hypotension, bradycardia, and respiratory depression. In case of suspected overdose, seek immediate medical attention or contact a poison control center. Supportive care is primary; activated charcoal may be considered if presented early.

Storage

Store at room temperature (20–25°C or 68–77°F), away from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

(Note: Individual experiences may vary. Consult your healthcare provider for personalized information.)

• “Zanaflex significantly reduced my muscle tightness and improved my mobility.” – Patient with MS
• “Effective for spasms, but caused drowsiness initially. Dose adjustment helped.” – User with spinal injury
• “Works quickly when I need it. Important to take exactly as prescribed.” – Long-term user