Placentrex is a biologically derived therapeutic agent, formulated from human placental extract, designed to support and accelerate tissue regeneration and wound healing processes. As a prescription medication, it is indicated for a range of conditions where cellular repair, anti-inflammatory action, and angiogenesis are clinically desired. Its mechanism is rooted in modulating the body’s innate healing pathways, offering a targeted approach to managing chronic ulcers, non-healing wounds, and certain inflammatory disorders. This expert-oriented guide details its composition, clinical applications, and essential pharmacotherapeutic information for healthcare professionals.

Features

• Contains biologically active components derived from human placental extract
• Exhibits anti-inflammatory, immunomodulatory, and angiogenic properties
• Available in multiple formulations including gel for topical application and injection for intramuscular or local use
• Standardized extraction and purification process ensuring batch-to-batch consistency
• Supports extracellular matrix synthesis and fibroblast proliferation

Benefits

• Accelerates wound epithelialization and granulation tissue formation in chronic wounds
• Reduces local inflammation and associated pain in affected tissues
• Enhances microcirculation and promotes angiogenesis in ischemic tissues
• Supports recovery in post-surgical healing and radiation-induced tissue damage
• May improve symptomatic relief in conditions like osteoarthritis and pelvic inflammatory disease
• Contributes to reduced healing time and lower risk of secondary infections

Common use

Placentrex is commonly used in the management of non-healing wounds such as diabetic foot ulcers, venous stasis ulcers, and pressure sores. It is also employed in the treatment of burns, post-operative wounds, and tissue injuries resulting from trauma. In its injectable form, it is used for conditions like osteoarthritis, non-specific vaginitis, and pelvic inflammatory disease, where its anti-inflammatory and regenerative actions provide therapeutic benefit. Dermatological applications include its use in certain eczematous disorders and radiation dermatitis.

Dosage and direction

Topical Gel: Apply a thin layer on the affected area 2–3 times daily, after cleaning the wound thoroughly. Cover with a sterile dressing if indicated.
Injection (IM): Typically 2 mL administered intramuscularly daily or on alternate days, as prescribed. Treatment duration varies based on condition severity and response.
Local Injection: For conditions like osteoarthritis, 1–2 mL may be injected locally into the affected joint periodically under aseptic conditions.
Always follow specific prescribing instructions; duration of therapy should be individualized based on clinical evaluation.

Precautions

• Use under strict medical supervision; self-administration is not advised.
• Topical application should be avoided on infected wounds unless concomitant antimicrobial therapy is used.
• Pregnant or breastfeeding women should use only if clearly indicated and under physician guidance.
• Monitor for signs of hypersensitivity during initial uses.
• Storage must be as per recommended conditions to maintain stability.

Contraindications

• Known hypersensitivity to any component of placental extract or formulation excipients.
• Active systemic infections or febrile illnesses (relative contraindication for injectable form).
• Application on malignant wounds or tissues with suspected neoplasia.
• Not recommended in patients with severe hepatic or renal impairment without medical oversight.

Possible side effect

• Local reactions: Mild burning, itching, or redness at application or injection site.
• Allergic manifestations: Rash, urticaria, or in rare cases, anaphylaxis (more common with injectable form).
• Systemic effects: Malaise, low-grade fever, or dizziness occasionally reported with injections.
• Usually mild and transient; discontinue if severe or persistent reactions occur.

Drug interaction

No well-documented pharmacokinetic drug interactions are established. However, caution is advised when using with other immunomodulators or biologics. Theoretical potential for altered effects when used concomitantly with strong anti-inflammatory agents; clinical monitoring recommended.

Missed dose

If a dose is missed, apply or administer as soon as remembered. If it is nearly time for the next dose, skip the missed dose and resume the regular schedule. Do not double the dose to catch up.

Overdose

No specific antidote is known. Topical overdose is unlikely due to limited systemic absorption. In case of accidental injection overdose, symptomatic and supportive treatment should be provided. Medical attention should be sought if adverse symptoms appear.

Storage

Store below 25°C, protected from light and moisture. Do not freeze. Keep out of reach of children. Discard any unused portion after the treatment period or by the expiration date, whichever is earlier.

Disclaimer

This information is intended for healthcare professionals and is not a substitute for clinical judgment or prescribing guidelines. Always refer to the full prescribing information and approved product literature. Use only as directed by a qualified medical practitioner.

Reviews

“Placentrex has shown consistent results in our wound care clinic, particularly in diabetic ulcer patients where conventional treatments had limited success.” – Wound Care Specialist, Delhi
“Injectable form provided significant symptomatic relief in chronic osteoarthritis patients, with reduced dependency on NSAIDs.” – Rheumatologist, Mumbai
“An important adjunct in managing non-healing wounds; its angiogenic property stands out in ischemic tissue cases.” – Vascular Surgeon, Chennai
“Good safety profile and patient compliance with topical formulation in dermatology practice.” – Dermatologist, Kolkata
“Further robust clinical trials would help in standardizing its use across a broader range of indications.” – Clinical Pharmacologist, Bangalore