Gyne-Lotrimin is a leading over-the-counter antifungal medication specifically formulated to treat vulvovaginal candidiasis. Containing the active ingredient clotrimazole, a well-established imidazole antifungal, it targets the causative organisms—primarily Candida albicans—by disrupting their cell membrane integrity. This topical cream provides symptomatic relief from itching, burning, and discharge, and is indicated for self-treatment in patients with a prior physician diagnosis of a vaginal yeast infection. Its efficacy and safety profile are supported by decades of clinical use and dermatological testing.

Features

• Active Ingredient: Clotrimazole 1% (2% also available in certain formulations)
• Dosage Form: Topical cream for external vulvar application; also available as intravaginal inserts/tablets
• Mechanism of Action: Fungistatic and fungicidal; inhibits ergosterol synthesis, a key component of fungal cell membranes
• Presentation: Typically supplied in 1 oz (28 g) tubes with measured-dose applicator for precise administration
• Excipients: Benzoic acid, cetyl esters wax, cetyl palmitate, octyldodecanol, purified water, and sorbitan monostearate; formulated for minimal irritation
• Onset of Action: Symptomatic relief often begins within a few days; full microbiological cure typically requires complete course
• OTC Status: Available without prescription for self-treatment of recurrent infections in diagnosed patients

Benefits

• Provides rapid relief from pruritus, erythema, and burning associated with vulvovaginal candidiasis
• Offers high cure rates with a complete treatment course, reducing risk of recurrence when used as directed
• Minimal systemic absorption ensures targeted action with low risk of systemic side effects
• Convenient once- or twice-daily dosing supports adherence to treatment regimen
• Suitable for use in non-pregnant patients with previously diagnosed yeast infections
• Prevents further proliferation of yeast, helping restore normal vaginal flora balance

Common use

Gyne-Lotrimin is primarily used for the treatment of uncomplicated vulvovaginal candidiasis. It is appropriate for patients who have previously been diagnosed by a healthcare provider with a yeast infection and are experiencing a recurrence of characteristic symptoms, such as vulvar itching, soreness, burning, and curd-like discharge. It is not intended for initial self-diagnosis; patients experiencing symptoms for the first time, or those with severe, persistent, or frequently recurring infections, should seek medical evaluation to confirm the diagnosis and rule out other causes (e.g., bacterial vaginosis, trichomoniasis, or sexually transmitted infections). It may also be used adjunctively with oral antifungals in some cases of more persistent infection, under medical guidance.

Dosage and direction

For external vulvar use (cream):

• Wash hands thoroughly before and after application.
• Apply a thin layer of the cream to the affected external vulvar area twice daily, in the morning and at night.
• Gently massage into the skin until absorbed.
• Continue use for the full course of treatment (typically 7 days), even if symptoms improve sooner, to prevent recurrence.

For intravaginal use (if applicable; refer to specific product labeling):

• Use the applicator provided to insert the cream or tablet intravaginally, usually once daily at bedtime.
• Lie on your back with knees bent for insertion.
• Wash the applicator with mild soap and warm water after each use.

Complete the full prescribed course unless otherwise directed by a physician.

Precautions

• For external use only. Avoid contact with eyes. If contact occurs, rinse thoroughly with water.
• Do not use tampons, douches, or spermicidal agents concurrently, as they may alter efficacy or cause irritation.
• Refrain from sexual intercourse during treatment to prevent reinfection or transfer to partner; condoms and diaphragms may be weakened by the oil base and fail.
• Discontinue use and consult a healthcare provider if symptoms persist after 7 days, worsen, or return within 2 months.
• Not for use in children under 12 years of age unless directed by a physician.
• Patients with diabetes or immunocompromised conditions (e.g., HIV, chemotherapy) should consult a provider before use.

Contraindications

• Hypersensitivity to clotrimazole, any other imidazole antifungals, or any ingredient in the formulation.
• Patients without a previous healthcare provider diagnosis of a yeast infection.
• Suspected or confirmed bacterial, parasitic, or viral vaginal infections.
• Pregnancy (unless advised by a physician; some formulations may be used in second and third trimesters under supervision).
• Open wounds, sores, or broken skin in the application area.

Possible side effect

Most side effects are local and mild. They may include:

• Mild burning, itching, or irritation at the application site
• Skin rash, redness, or swelling
• Abdominal cramps or discomfort
• Headache
• Uncommon: allergic contact dermatitis, hives, or blistering

Discontinue use and seek medical attention if severe irritation or signs of allergic reaction (e.g., difficulty breathing, swelling of face/lips/tongue) occur.

Drug interaction

Clotrimazole is minimally absorbed systemically, so significant drug interactions are rare. However, note:

• May inactivate condoms and diaphragms due to oil-based ingredients; use alternative barrier methods.
• Theoretical potential to interact with other vaginally administered products; avoid concurrent use.
• No known interactions with oral contraceptives or systemic medications, but consult a provider if uncertain.

Missed dose

Apply the missed dose as soon as remembered, unless it is almost time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule.

Overdose

Topical overdose is unlikely due to minimal systemic absorption. If the product is ingested orally, seek medical attention or contact a poison control center immediately. Symptoms of oral ingestion may include nausea, vomiting, and gastrointestinal discomfort.

Storage

• Store at room temperature (15–30°C or 59–86°F).
• Keep tube tightly closed.
• Do not freeze.
• Keep out of reach of children and pets.
• Discard any unused product after the treatment course is complete.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read here. Self-diagnosis and self-treatment are not recommended for vaginal symptoms without prior medical diagnosis.

Reviews

(Compiled from verified consumer feedback and clinical summaries)

• Many users report significant relief from itching and discomfort within 2–3 days of use.
• Appreciated for its ease of application and lack of greasy residue compared to some other antifungal creams.
• Some note that complete symptom resolution requires full course adherence.
• A small number of users experienced mild initial burning or skin sensitivity.
• Frequently recommended by gynecologists for recurrent yeast infection management in appropriate patients.