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Udenafil is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate).
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Udenafil is a therapeutic agent hypothesized to improve erectile function endpoints through interaction with the phosphodiesterase type 5 (PDE5) enzyme. Udenafil has unique properties, with a T max of 1.0-1.5 h and a T 1/2 of 11-13 h (a relatively rapid onset and a long duration of action). Therefore, both on-demand and once-daily use of Udenafil have been reported. Udenafil's efficacy and tolerability have been evaluated in several studies, and recent and continuing studies have demonstrated Udenafil's promise in both dosing regimens. Udenafil as an on-demand or once-daily dose is effective and tolerable, but more studies are needed in patients of other ethnicities and with comorbid conditions such as diabetes mellitus, hypertension, and benign prostate hyperplasia.


Dosage and direction


Zudena is taken inside, regardless of the meal.


Recommended dose- 100 mg, taken 30 minutes before anticipated sexual activity.


The dose may be increased to 200 mg given individual efficacy and tolerability.


The maximum recommended frequency of application - 1 times per day.


Do not break or split a Zudena tablet. Swallow it whole.


Precautions


Sexual activity is a potential risk for patients with cardiovascular disease, so treatment of erectile dysfunction, including using of Udenafil, should not hold for men with heart disease, in which sexual activity is not recommended.


Patients with obstruction of blood outflow from the left ventricle (aortic stenosis) may be more sensitive to the action of vasodilators, including inhibitors of PDE. Despite the lack of clinical trials of cases of prolonged erection (longer than 4 hours) and priapism (painful erections lasting more than 6 h), such phenomena are peculiar to this class of drugs. In the event of an erection lasting more than 4 hours (regardless of pain), patients should immediately seek medical help. In the absence of timely treatment of priapism can lead to irreversible damage to the erectile tissue and erectile function.


List of those who must take Zudena with extra caution: Patients with uncontrolled hypertension (blood pressure> 170/100 mm Hg.), hypotension (blood pressure <90/50 mmHg..); Patients with hereditary degenerative diseases of the retina (including retinitis pigmentosa, proliferative diabetic retinopathy); Patients who have undergone over the last 6 months of stroke, myocardial infarction or coronary artery bypass grafting; Patients with severe hepatic or renal impairment; presence of congenital long QT syndrome, or an increase in the QT interval as a result of taking the drugs; predisposition to priapism; patients with anatomical deformation of the penis; the presence of penile implant; sexual activity in patients with diseases of the cardiovascular system such as unstable angina or angina occurring during sexual intercourse, chronic heart failure (II-IV functional class NYHA classification), which developed during the last 6 months, uncontrolled heart rhythm disorders, - should take into account the potential risk of complications; while receiving of Udenafil and CCBs, alpha-blockers or other hypotensive drugs - may mark the additional reduction in SBP and DBP by 7-8 mmHg.


According to the registered indication the drug is not intended for use in women.


The drug is not intended for use under the age of 18 years.


Contraindications


Do not use Udenafil in combination with other treatments for erectile dysfunction.


Hypersensitivity to any component of the drug; simultaneous reception of nitrates and other donor of nitric oxide. Do not take Udenafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking Udenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.


Effects on ability to drive and operate machinery. Before you manage the equipment and vehicles, patients need to know how they react to the reception of Zudena.


Possible side effect


Get emergency medical help if you have signs of an allergic reaction to Udenafil: hives, difficult breathing, your face, lips, tongue, or throat swelling.


Stop using Zudena and get emergency medical help if you have: Palpitations, prolonged erections, flushing, dizziness eye pain, increased lacrimation, nasal congestion, headache.


There is no research for its side effects for the men over 71 y.o.


There are no side effects on sperm quality.


In case you notice any of these side effects or other not listed above - contact your doctor or pharmacist.


Drug interaction


Consult your doctor before taking Udenafil. Tell your doctor about all your current medicines and any you start or stop using, especially:


- Inhibitors of cytochrome P450 isoenzyme CYP3A4 (ketoconazole, itraconazole, ritonavir, indinavir, cimetidine, erythromycin, grapefruit juice) may enhance the action of Udenafil.


- Ketoconazole (400 mg) increases the bioavailability and Cmax of Udenafil (100 mg) almost 2-fold (212%) and 0.8-fold (85%), respectively.


- Ritonavir and indinavir substantially increases the effects of Udenafil.


- Dexamethasone, rifampin, and anticonvulsants drugs (carbamazepine, phenytoin and phenobarbital) may accelerate the metabolism of Udenafil, so joint application with the above medications weakens the effect of Udenafil.


- The joint application of Udenafil (30 mg / kg orally) and nitroglycerin (2.5 mg / kg once, w / w) did not reveal any effect on the pharmacokinetics of Udenafil in experimental studies, but the simultaneous use of nitroglycerin and of Udenafil is not recommended because of possible reduce blood pressure.


- Udenafil and drugs from the group of alpha-blockers are vasodilator, therefore, in the joint admission should be appointed at the minimum doses.


Missed dose


If Zudena is used as needed, you are not likely to be on a dosing schedule. The maximum recommended frequency of application - 1 times per day.


Overdose


Symptoms: with single dose of the drug in a dose of 400 mg of adverse events were comparable to those observed when receiving of Udenafil at lower doses, but occurred more frequently.


Treatment: symptomatic. Dialysis does not accelerate the elimination of Udenafil.


If you think you have used too much of Zudena - seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Storage


Store Zudena in a dry, dark place at a temperature no higher than 86° F (30° C). Do not store drugs in the bathroom. Keep all drugs out of the reach children and pets.


Disclaimer


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Asthma Treatment

Asthma is a chronic inflammatory disease of the respiratory tract. In cases of predisposition this inflammation causes recurring cough, stertor, the feeling of pressure in the chest, difficulty breathing. The inflammation makes the respiratory tract sensitive to allergens, chemical irritants, tobacco smoke, cold air and physical exercise. These irritants cause swelling and respiratory tract spasm, increased quantities of mucous are produced and the respiratory tract becomes hypersensitive to external affections. If the condition is adequately treated then the inflammation may decrease for a long period of time as well as frequency of symptom appearance decreases, concomitant symptoms of bronchial asthma may also disappear.

By severity of the disease 4 forms of asthma are distinguished:

  • Intermittent
  • Mild remission
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  • Severe persistent

The disease most frequently proceeds in classical form as suffocation episodes followed by remission periods.

Bronchial asthma treatment depends on the period of the disease. During the acute episodes it is necessary to inhibit it as soon as possible with broncho-spasmolytic drugs, which may belong to different groups: stimulators of adrenergic receptors, theophylline, methylxanthines.

During the remission period of bronchial asthma specific immunotherapy(hyposensibilization) may be performed. A very important part of the therapy consists in exercise, rational nutrition, daily regimen which will include long periods of time in contact with fresh air.

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Nearly 300 million people were affected worldwide and about 20 million of people suffer in USA suffer from asthma. In 2009 asthma caused 250,000 deaths globally. Asthma affects people of all ages, but it most often starts during childhood. In the United States, more than 22 million people are known to have asthma. Nearly 6 million of these people are children.

Asthma is a long-term disease that can't be cured. Asthma medicines can be either inhaled, using a metered dose inhaler, dry powder inhaler, or a nebulizer, or taken orally, either in pill or liquid form. Medications can also be given by injection. An inhaler allows the medicine to go directly to your lungs where it is needed most.

What is Albuterol / Ventolin Inhaler

Due to the fact that there is no cure for asthma and other associated lung diseases, you will always find that most of the methods have been initiated to help in controlling these conditions. Generic albuterol inhaler is one of these methods that in most cases will help you in controlling your asthma conditions.Genetic albuterol inhaler is always prescribed to help you in managing the asthma conditions in your body especially exercise induced asthmas conditions. Apart from asthma, this prescription can also help you to deal with other lung associated diseases. Due to the fact that the old typesof genetic albuterol inhale were a threat to both the users and environment, you will never get them in the current market.This is because they always contain some chlorofluorocarbons which are always a threat to your health and also poses some danger to the atmosphere.

When looking for the current generic albuterol inhale, in most cases you will get them inform of Proair HFA, Proventil HFA, or Ventolin HFA. You should always make sure that you do not confuse these kinds of medicine with others sharing the same prefix. It is estimated that the next new batch or version of generic albuterol inhaler it will be in the market by 2014. It is expected that the ventolin HFA version to expire by the year 2015 by October to be more precise. If you need to get some benefit of this kind of medicine, this is the right time for you to have the medicine.

Ventolin Inhalers is the preferred medicines for long-term control of asthma. Ventolin Inhaler i.e. Albuterol is belongs to a class of medications called bronchodilators or beta-agonists (helps easier breathing by telling the muscles of the airways to relax, widening the airways). VENTOLIN HFA (albuterol sulfate inhalation aerosol) is indicated for the treatment or prevention of bronchospasm with reversible obstructive airway disease and prevention of exercise-induced bronchospasm. It works very quickly to relieve asthma attacks, wheezing, chest tightness or shortness of breath. Ventolin hfa inhalers works by relaxing the muscles in the walls of the small airways in the lungs. This helps to open up the airways and make breathing easier. They're the most effective option for long-term relief of the inflammation and swelling that makes your airways sensitive to certain inhaled substances. Albuterol (over the counter asthma drug) is also used to prevent the symptoms of exercise-induced asthma.

Care should always be taken especially when you are using generic albuterol inhale. This is because it may result to other body complications if you use the medicine wrongly. Therefore it is important to always follow the prescriptions given by your health care provider especially if good results and fast healing is your targets.

This medicine should always be used for the right purpose and by the right person. It is always good to put it always from the reach of children and a safe place when not in use. Still when you are using it, it is also good and advisable to put away from fire. This is because it may explode thus causing some other unplanned inconveniences.

Generic albuterol inhale: cost and affordability

Though the new generic albuterol inhales always much more effective on how they deal with lung related condition, you will always find them to be a bit more expensive than the old versions. This should not worry you because having them, you are always guaranteed that you will be able to deal with all lung related infections which are life-threatening conditions. The other alternative that you can always use is the various programs which are usually available in most of health facilities. There are various sources that you can always get this medicine ranging from the local pharmaceuticals to the international source but considering an online source is always good for you. This is because it is always a reliable and an easier way to purchase generic albuterol inhale. Online method is also good for you because it always saves your time and cost for the medicine.

Generic albuterol inhale dosage

When treating asthma, it usually advisable you start with one to two sprays especially for the exercises related asthmas. Before you start exercising, it is recommended that you take about two sprays about 15-30 minutes before. In most cases when there are no changes with the use of this prescription, it is always good that you seek for a health provider intervention so that you can get another kind of medication. In order to prevent some of the shortcoming associated to asthma, it is always good that you carry your generic albuterol inhale with you in order to use when there is an emergency.

How to Use a Metered Dose Inhaler / Ventolin Inhaler

In most cases when using generic albuterol inhale, it is always advisable that you spry about once or twice especially before you start your exercises. This helps in preventing asthma that is induced by exercises related activities. It is usually recommended that you do it about 15-30 minutes before the actual time for your exercises. If the condition arises during the exercises and it happens that it is worse than usual, you are supposed to seek for a physician help since it may put your life at risk.

When starting your generic albuterol inhale medication, in most cases you will find that your health provider has to consider some factors before prescribing you with any medicine of this kind. One of the condition is what you are intending to do with the medicine. Is it preventing or treating asthma? He or she also considers whether you have other diseases affecting you and if there are no diseases, what is your asthmatic severity. This helps you in getting the proper dose that will work on your condition in the right way without altering your body functionality.Apart from this consideration, it is always important to always inform your physician about other medicine that you are also taking before you begin using generic albuterol inhale. This help in knowing the amount you are supposed to take. It also important for interaction purposes due to the fact that other medications may affect how your new medicine works in your body asthmatic condition.

After you receive your asthma prescriptions, it is always good to remember to carry it with you to wherever you are going. This is because the condition may arise at any point especially when you are not prepared for it. This can be serious especially if the asthma is allergic to atmospheric changes. In cases when you do not see any changes with the use of generic albuterol on your health, it is always important to seek for a medical intervention immediately. This is because the condition may put your life at risk especially if it is the first time to be affected by the asthma.

How you intend to use the medicine as mentioned earlier is important. This is because some people always use generic albuterol for preventing asthma attack while others use it to manage the condition. It is therefore important to always test the medication before you start using it. This helps you to be aware that the prescription is really working in order to prevent some inconveniences when the condition arises.When inhaling, it is important you always shake the medicine well and also to wait for about a minute before you use it. Learning these simple but important tips for using your generic albuterol inhale helps in avoiding difficulties and other shorting comings that accompany the use of this medicine.

Remember also that this medicine should always be used in your lungs but not just spraying at the back of your throat as many do. You should also not swallow the medicine. In order to avoid all these short comings, it is always advisable when using it to always breathe in. apart from this technique, most health care professionals always tells people with this condition to always place the inhale about one to two inches always from their mouth. This helps you in preventing direct swallowing the medicine. For more information on how to use generic albuterol inhale, you should always make sure that you contact your health provider for more directions.

In most cases your generic albuterol inhale contains about 200 sprays. It is always good to track how you are using it in order to replace it when need arises. Unlikethe older versions of this medicine which was hard to track their uses, the new version especially the Ventolin HFA has an automatic counter that help you in put track of your medicine use. In most cases, it is always good to be around other people so that in case of emergency you can always get help from them. If you have problems in using your generic albuterol inhale in the right ways, a professional interventions is always recommended for you.