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Generic Copegus (Ribavirin)
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Copegus
Copegus is used to treat chronic hepatitis C which is a disease of the liver. It helps the immune system fight the hepatitis C virus, and make it harder for the virus to reproduce within the body.
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Depression and other psychiatric conditions: This medication can cause depression and other psychiatric conditions. Copegus or unstable cardiac disease: not recommended. Do not give this medication to anyone else, even if they have the same symptoms as you do. Terms and conditions of use. Search for. Daily news summary. Capsules Coepgus Ribavirin Generic from Teva. Testing for ribavirin Copegks is not commercially available. Pediatric Patients Upon resolution of a laboratory abnormality or clinical adverse reaction, an increase in COPEGUS Copegue to the original dose may be attempted depending upon the physician's judgment. Table Copegu Contents. Publications automatically indexed to this study by ClinicalTrials. Adult Patients older than 18 years of age. Created at University of Washington. The most commonly reported adverse reactions were psychiatric reactions, including depression, insomnia, irritability, anxiety, and flu-like symptoms such as fatigue, pyrexia, myalgia, headache and rigors. Start the conversation about hepatitis C with your doctor by building a personalized discussion guide. Ribavirin causes hemolytic anemia. Copegus, available as a mg tablet, is administered at to mg taken twice daily as a split dose. Children: Take with food in 2 divided doses, with peginterferon alfa-2a. Are you at risk? Benzyl alcohol has been reported to be associated with an increased incidence of neurological and other complications in neonates and infants, which are sometimes fatal. Daily news summary. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Funded by a grant from the. Pediatric Patients 5 to 18 years of age. Pegasys and Copegus therapy is additionally contraindicated in women who are pregnant, men whose female partners are pregnant and patients with hemoglobinopathies eg, thalassemia major, Coepgus -cell anemia. This medication is a combination of two different medications: peginterferon alfa-2a and ribavirin. Treat for 48 weeks Genotype 1, 4 or 24 weeks Genotype 2, 3. Pharmacokinetic behavior of the end product depends on the length of the PEG and the nature of the link between the PEG and the protein. Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. Federal Government. Therapy should be withdrawn in patients with persistently severe or worsening signs or symptoms of these conditions. Despite older, sicker patients, mortality rate fell by a third in 10 years. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. December 9, Create a personalized discussion guide to use when talking with your doctor. Pegasys has been approved for use in more than 50 c ountries, including all European Union countries. Arms and Interventions. Declining lung cancer mortality helped fuel the progress. If left untreated, hepatitis C Copegus Copeyus fatal for Coprgus patients. Use this Search to quickly find items or navigate the site. With peginterferon alfa-2a: autoimmune hepatitis, Copevus decompensation in cirrhotic patients before therapy. For more information on the Roche pharmaceuticals business in the United States, visit the company's website at: www. Recent Headlines. Boxed Warning: Risk of serious disorders and ribavirin-associated effects. Ribavirin causes hemolytic anemia. Hoffmann-La Roche Inc. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Photo: Andrew Karpenko, University of Washington. If you experience any changes in vision while taking this medication, contact your doctor. Explore Apps. Patients should be monitored closely with periodic clinical and laboratory evaluations. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect. Copegus will be available in early History of heart failureheart attack or irregular heartbeats arrhythmias. In 18 subjects with ESRD Copeyus chronic HD, Copegus was administered at a dose of mg daily with no apparent difference in the adverse event profile in comparison to subjects with normal Copeegus function. Fatal and nonfatal myocardial infarctions have been reported in patients with anemia caused by Copegus. Patients should be assessed for Copegus cardiac disease before initiation of Copegs therapy. For more information on the Roche pharmaceuticals business in the United States, visit the company's website at: www. Daily news summary. Contraception should be started before your treatment begins and continued all the time you are taking this medicine. Food and Drug Administration FDA has approved combination therapy with Pegasys" peginterferon alfa-2aa pegylated interferon, and Copegus ribavirin for the treatment of adults with chronic hepatitis C who have compensated liver disease and have not previously been treated with interferon alpha. More From Infections. Because many drugs are excreted in human milk and to avoid any potential for serious adverse reactions in nursing infants from ribavirin, a decision should be made either to discontinue nursing or therapy with Copegus, based on the importance of the therapy to the mother. Patients should be instructed to use at least two forms of effective contraception during treatment and for 6 months after treatment has been stopped. The most common adverse event associated with ribavirin is anemia, which may be severe [see Boxed WarningWarnings and Precautions 5. Lung disorders: Certain lung disorders may occur in people using this medication. Subscribe to our newsletters. Copetus Engl J Med. The two products will be sold separately. Pegasys and Copegus therapy is additionally contraindicated in women who are pregnant, men whose female partners are pregnant and patients with hemoglobinopathies eg, thalassemia major, sickle -cell anemia. Metabolism and nutrition disorders. Daily news summary. Copegus in combination with PEGASYS peginterferon alfa-2a is indicated for the Copegus of patients 5 years of age and older with chronic hepatitis C CHC virus infection who have compensated liver disease and have not been previously treated with interferon alpha. No data are available for pediatric subjects with renal impairment. In all treatment arms, patients with viral genotype 1, regardless of viral load, had a lower response rate to PEGASYS in combination with Copegus compared to patients with other viral genotypes. Tablets - Ribavirin Copegus. February 8, Gastrointestinal disorders. Save this study. National Library of Medicine U. The effect of hepatic impairment on the pharmacokinetics of ribavirin following administration of Copegus has not been evaluated. However, peginterferon alfa-2a and ribavirin when administered separately, each has adverse effects on reproduction. Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients. The number of patients who received medication in the study was Pegasys was approved as monotherapy for the treatment of adults with chronic hepatitis C on October 16, All rights reserved. In both studies, virus genotype was clearly the strongest predictor of whether or not a patient achieved a sustained virological response. View Older Articles. Potential contamination could lead to supply chain disruptions. Terms and conditions of use. Study Copegus posted prices finds wild variations and missing data. Go Ahead. It is very important for women and men taking this medicine, and female partners of men taking this medicine, to use effective methods of contraception to avoid exposing a developing baby to the medicine. For more information on the Roche pharmaceuticals business in the United States, visit the company's website at: www. The side effects listed above may not include all of the side effects reported by the drug's manufacturer. The anemia associated with ribavirin therapy may result in worsening of cardiac disease. If you have a thyroid condition, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you have diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. In many, but not all cases, these disorders resolve after stopping Pegasys therapy.
Common use

Copegus is used together with an interferon (such as PegIntron or Intron A) to treat chronic hepatitis C which is a disease of the liver. This is a drug for the patients who have not been treated with interferon previously or who have had a return of hepatitis C following successful treatment with interferon. It helps the immune system fight the hepatitis C virus, and make it harder for the virus to reproduce within the body. Copegus belongs to the antivirals.



Dosage and direction

The usual dose of Copegus per day is 800 mg, 1,000 mg, or 1,200 mg i orally in two divided doses (morning and evening) with food for 24 or 48 weeks. The dose and duration of treatment depend on your condition, on body weight, on baseline disease characteristics, response to therapy and tolerability of the regimen. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. It should be taken consistently. For example, it should be taken at the same time or times each day and each time.



Precautions

Copegus may decrease the number of red blood cells in your body (anemia) and it can be life-threatening in people who have heart disease or circulation problems. Careful consideration is advised if Copegus is used in patients with heart or circulation problems since the anemia may aggravate these conditions. Your blood will need to be tested often. Also your vision, liver function and thyroid function may also need to be tested. Visit your doctor regularly. Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, weakness, or trouble breathing. Copegus may cause birth defects and/or death in unborn babies that are exposed to it during pregnancy. If you or your sexual partner are or may be pregnant, do not take Copegus, and contact your doctor immediately. Women and men who are taking Copegus must avoid pregnancy during treatment with this drug and for 6 months after this medication has been stopped. Consult your doctor or pharmacist for more information.



Contraindications

Before taking Copegus you should talk with your doctor if you are allergic to peginterferon alfa-2a, any other interferon, ribavirin, polyethylene glycol, or to any of the ingredients of the medication, if you are an infant, breast-feeding, pregnant or has a pregnant partner. Also in the way if you have decompensated liver disease, hemoglobinopathies (thalassemia, sickle-cell anemia), HIV-HCV (human immunodeficiency virus and hepatitis C virus) with cirrhosis and a baseline Child-Pugh score greater than or equal to 6. And you should discuss with your doctor if you have a severe psychiatric disorder, autoimmune diseases (including autoimmune hepatitis), thyroid problems not controlled by medication even in the past.



Possible side effects

The most common side effect of Copegus is a flu-like syndrome consisting of body aches and pains, fever, chills, headache and malaise. The most serious side effect is anemia. Patients with certain types of heart disease should not use Copegus. This may make your condition worse and can lead to a possibly fatal heart attack. Copegus should be avoided among patients who have severe kidney disease and have lost most of their kidneys' function. Therapy with Copegus and interferon may aggravate psychiatric conditions or may cause a psychiatric condition such as depression, suicidal ideation, psychosis, aggressive behavior, hallucinations, or violent behavior. Patients should be closely monitored for the development of these psychiatric conditions. Therapy has caused abnormalities of the thyroid gland. If these abnormalities persist and cannot be controlled by medication, it may be necessary to finish this therapy. Other possible side effects that may occur during therapy with Copegus are fatigue, weakness, nausea, anorexia, heartburn, insomnia, irritability, difficulty breathing, rash, itching, and alterations in taste perception.



Drug interactions

If Copegus is used with other antiviral drugs with similar mechanisms of action it may cause a condition in which lactic acid accumulates in the blood (lactic acidosis). This situation can lead to serious medical problems. Also do not take Copegus with antiviral drugs that used to manage HIV infection (zidovudine (Retrovir), zalcitabine (Hivid) or stavudine (Zerit)).



Missed dose

If you miss a dose of Copegus, take the missed dose as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.



Overdose

Overdose symptoms may include easy bruising or bleeding, urinating less than usual or not at all, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, or a general ill feeling. If you experience something from list above you need emergency medical attention.



Storage

Store Copegus in the refrigerator, protect them from light, and keep them out of the reach of children. Do not freeze, shake, or use them past the expiry date.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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Asthma Treatment

Asthma is a chronic inflammatory disease of the respiratory tract. In cases of predisposition this inflammation causes recurring cough, stertor, the feeling of pressure in the chest, difficulty breathing. The inflammation makes the respiratory tract sensitive to allergens, chemical irritants, tobacco smoke, cold air and physical exercise. These irritants cause swelling and respiratory tract spasm, increased quantities of mucous are produced and the respiratory tract becomes hypersensitive to external affections. If the condition is adequately treated then the inflammation may decrease for a long period of time as well as frequency of symptom appearance decreases, concomitant symptoms of bronchial asthma may also disappear.

By severity of the disease 4 forms of asthma are distinguished:

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  • Mild remission
  • Moderate persistent
  • Severe persistent

The disease most frequently proceeds in classical form as suffocation episodes followed by remission periods.

Bronchial asthma treatment depends on the period of the disease. During the acute episodes it is necessary to inhibit it as soon as possible with broncho-spasmolytic drugs, which may belong to different groups: stimulators of adrenergic receptors, theophylline, methylxanthines.

During the remission period of bronchial asthma specific immunotherapy(hyposensibilization) may be performed. A very important part of the therapy consists in exercise, rational nutrition, daily regimen which will include long periods of time in contact with fresh air.

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Nearly 300 million people were affected worldwide and about 20 million of people suffer in USA suffer from asthma. In 2009 asthma caused 250,000 deaths globally. Asthma affects people of all ages, but it most often starts during childhood. In the United States, more than 22 million people are known to have asthma. Nearly 6 million of these people are children.

Asthma is a long-term disease that can't be cured. Asthma medicines can be either inhaled, using a metered dose inhaler, dry powder inhaler, or a nebulizer, or taken orally, either in pill or liquid form. Medications can also be given by injection. An inhaler allows the medicine to go directly to your lungs where it is needed most.

What is Albuterol / Ventolin Inhaler

Due to the fact that there is no cure for asthma and other associated lung diseases, you will always find that most of the methods have been initiated to help in controlling these conditions. Generic albuterol inhaler is one of these methods that in most cases will help you in controlling your asthma conditions.Genetic albuterol inhaler is always prescribed to help you in managing the asthma conditions in your body especially exercise induced asthmas conditions. Apart from asthma, this prescription can also help you to deal with other lung associated diseases. Due to the fact that the old typesof genetic albuterol inhale were a threat to both the users and environment, you will never get them in the current market.This is because they always contain some chlorofluorocarbons which are always a threat to your health and also poses some danger to the atmosphere.

When looking for the current generic albuterol inhale, in most cases you will get them inform of Proair HFA, Proventil HFA, or Ventolin HFA. You should always make sure that you do not confuse these kinds of medicine with others sharing the same prefix. It is estimated that the next new batch or version of generic albuterol inhaler it will be in the market by 2014. It is expected that the ventolin HFA version to expire by the year 2015 by October to be more precise. If you need to get some benefit of this kind of medicine, this is the right time for you to have the medicine.

Ventolin Inhalers is the preferred medicines for long-term control of asthma. Ventolin Inhaler i.e. Albuterol is belongs to a class of medications called bronchodilators or beta-agonists (helps easier breathing by telling the muscles of the airways to relax, widening the airways). VENTOLIN HFA (albuterol sulfate inhalation aerosol) is indicated for the treatment or prevention of bronchospasm with reversible obstructive airway disease and prevention of exercise-induced bronchospasm. It works very quickly to relieve asthma attacks, wheezing, chest tightness or shortness of breath. Ventolin hfa inhalers works by relaxing the muscles in the walls of the small airways in the lungs. This helps to open up the airways and make breathing easier. They're the most effective option for long-term relief of the inflammation and swelling that makes your airways sensitive to certain inhaled substances. Albuterol (over the counter asthma drug) is also used to prevent the symptoms of exercise-induced asthma.

Care should always be taken especially when you are using generic albuterol inhale. This is because it may result to other body complications if you use the medicine wrongly. Therefore it is important to always follow the prescriptions given by your health care provider especially if good results and fast healing is your targets.

This medicine should always be used for the right purpose and by the right person. It is always good to put it always from the reach of children and a safe place when not in use. Still when you are using it, it is also good and advisable to put away from fire. This is because it may explode thus causing some other unplanned inconveniences.

Generic albuterol inhale: cost and affordability

Though the new generic albuterol inhales always much more effective on how they deal with lung related condition, you will always find them to be a bit more expensive than the old versions. This should not worry you because having them, you are always guaranteed that you will be able to deal with all lung related infections which are life-threatening conditions. The other alternative that you can always use is the various programs which are usually available in most of health facilities. There are various sources that you can always get this medicine ranging from the local pharmaceuticals to the international source but considering an online source is always good for you. This is because it is always a reliable and an easier way to purchase generic albuterol inhale. Online method is also good for you because it always saves your time and cost for the medicine.

Generic albuterol inhale dosage

When treating asthma, it usually advisable you start with one to two sprays especially for the exercises related asthmas. Before you start exercising, it is recommended that you take about two sprays about 15-30 minutes before. In most cases when there are no changes with the use of this prescription, it is always good that you seek for a health provider intervention so that you can get another kind of medication. In order to prevent some of the shortcoming associated to asthma, it is always good that you carry your generic albuterol inhale with you in order to use when there is an emergency.

How to Use a Metered Dose Inhaler / Ventolin Inhaler

In most cases when using generic albuterol inhale, it is always advisable that you spry about once or twice especially before you start your exercises. This helps in preventing asthma that is induced by exercises related activities. It is usually recommended that you do it about 15-30 minutes before the actual time for your exercises. If the condition arises during the exercises and it happens that it is worse than usual, you are supposed to seek for a physician help since it may put your life at risk.

When starting your generic albuterol inhale medication, in most cases you will find that your health provider has to consider some factors before prescribing you with any medicine of this kind. One of the condition is what you are intending to do with the medicine. Is it preventing or treating asthma? He or she also considers whether you have other diseases affecting you and if there are no diseases, what is your asthmatic severity. This helps you in getting the proper dose that will work on your condition in the right way without altering your body functionality.Apart from this consideration, it is always important to always inform your physician about other medicine that you are also taking before you begin using generic albuterol inhale. This help in knowing the amount you are supposed to take. It also important for interaction purposes due to the fact that other medications may affect how your new medicine works in your body asthmatic condition.

After you receive your asthma prescriptions, it is always good to remember to carry it with you to wherever you are going. This is because the condition may arise at any point especially when you are not prepared for it. This can be serious especially if the asthma is allergic to atmospheric changes. In cases when you do not see any changes with the use of generic albuterol on your health, it is always important to seek for a medical intervention immediately. This is because the condition may put your life at risk especially if it is the first time to be affected by the asthma.

How you intend to use the medicine as mentioned earlier is important. This is because some people always use generic albuterol for preventing asthma attack while others use it to manage the condition. It is therefore important to always test the medication before you start using it. This helps you to be aware that the prescription is really working in order to prevent some inconveniences when the condition arises.When inhaling, it is important you always shake the medicine well and also to wait for about a minute before you use it. Learning these simple but important tips for using your generic albuterol inhale helps in avoiding difficulties and other shorting comings that accompany the use of this medicine.

Remember also that this medicine should always be used in your lungs but not just spraying at the back of your throat as many do. You should also not swallow the medicine. In order to avoid all these short comings, it is always advisable when using it to always breathe in. apart from this technique, most health care professionals always tells people with this condition to always place the inhale about one to two inches always from their mouth. This helps you in preventing direct swallowing the medicine. For more information on how to use generic albuterol inhale, you should always make sure that you contact your health provider for more directions.

In most cases your generic albuterol inhale contains about 200 sprays. It is always good to track how you are using it in order to replace it when need arises. Unlikethe older versions of this medicine which was hard to track their uses, the new version especially the Ventolin HFA has an automatic counter that help you in put track of your medicine use. In most cases, it is always good to be around other people so that in case of emergency you can always get help from them. If you have problems in using your generic albuterol inhale in the right ways, a professional interventions is always recommended for you.