Artvigil is a prescription medication containing armodafinil, the R-enantiomer of modafinil, designed to promote wakefulness in individuals with excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. It functions as a eugeroic agent, targeting specific neurotransmitter systems in the brain to enhance alertness without the typical stimulant side effects. Unlike traditional stimulants, Artvigil offers a smoother onset and sustained duration of action, making it a preferred choice for managing daytime sleepiness while supporting cognitive function.

Features

• Active ingredient: Armodafinil (150 mg per tablet)
• Pharmacological class: Eugeroic (wakefulness-promoting agent)
• Mechanism of action: Selective alpha1-adrenergic agonist; dopamine reuptake inhibitor
• Onset of action: Approximately 1–2 hours post-administration
• Duration of effect: Up to 12–15 hours
• Bioavailability: High oral bioavailability with peak plasma concentrations in 2–4 hours
• Formulation: Oral tablet, film-coated for ease of swallowing
• Packaging: Blister packs of 30 tablets, ensuring stability and portability

Benefits

• Promotes sustained wakefulness and reduces excessive daytime sleepiness, enabling improved daytime functioning.
• Enhances cognitive performance, including attention, memory, and executive function, without jitteriness or euphoria.
• Supports shift workers in maintaining alertness during non-traditional hours, reducing errors and improving productivity.
• Minimizes the need for frequent dosing due to its long half-life, offering convenience and consistency.
• Provides a favorable side effect profile compared to traditional stimulants, with lower risk of dependence.
• Improves quality of life for individuals with sleep disorders by facilitating normal daily activities and social engagement.

Common use

Artvigil is primarily indicated for the treatment of excessive sleepiness associated with narcolepsy, obstructive sleep apnea (OSA) with residual sleepiness despite primary airway therapy, and shift work sleep disorder (SWSD). In clinical practice, it is also sometimes used off-label under specialist supervision for attention deficit hyperactivity disorder (ADHD), fatigue associated with multiple sclerosis, and as an adjunct in depression with prominent fatigue. Its wakefulness-promoting properties make it suitable for individuals requiring prolonged mental alertness, though such uses must be carefully evaluated by a healthcare provider.

Dosage and direction

The recommended dosage of Artvigil is 150 mg taken orally once daily in the morning for narcolepsy or OSA. For shift work sleep disorder, it should be taken approximately 1 hour before the start of the work shift. Tablets should be swallowed whole with water and may be taken with or without food, though a light meal is advised to minimize potential gastrointestinal discomfort. Dosage adjustments are generally not required for elderly patients, but those with severe hepatic impairment should receive a reduced dose of 50–100 mg daily under close supervision. Do not crush, chew, or split the tablet.

Precautions

Patients should be advised to avoid alcohol while taking Artvigil, as it may alter the drug’s effectiveness and increase side effects. Use with caution in individuals with a history of hypertension, cardiovascular disease, or psychiatric disorders, as armodafinil may exacerbate these conditions. Artvigil may reduce the efficacy of hormonal contraceptives; alternative or additional non-hormonal methods of contraception should be used during and for one month after treatment. Patients should be monitored for signs of dermatologic reactions, including Stevens-Johnson syndrome, although such events are rare.

Contraindications

Artvigil is contraindicated in patients with known hypersensitivity to armodafinil, modafinil, or any component of the formulation. It should not be used in individuals with a history of symptomatic cardiovascular disease such as left ventricular hypertrophy, mitral valve prolapse, or angina. Use is also contraindicated in those with a history of psychosis or mania, due to the potential for exacerbation. Artvigil is not recommended during pregnancy or breastfeeding unless the potential benefit justifies the potential risk to the fetus or infant.

Possible side effect

Common side effects may include headache, nausea, dizziness, dry mouth, anxiety, and insomnia. Less frequently, patients may experience palpitations, increased blood pressure, diarrhea, or nervousness. Rare but serious adverse effects include severe skin reactions (e.g., Stevens-Johnson syndrome), psychiatric symptoms such as agitation or hallucinations, and cardiovascular events including chest pain or arrhythmia. Most side effects are mild to moderate and often diminish with continued use; however, any persistent or severe symptoms should be reported to a healthcare provider.

Drug interaction

Artvigil may interact with drugs that are substrates, inducers, or inhibitors of CYP3A4/5 enzymes. It can reduce the plasma concentrations of cyclosporine, ethinyl estradiol, and midazolam. Concurrent use with monoamine oxidase inhibitors (MAOIs) is not recommended due to the potential for increased blood pressure. Artvigil may also enhance the effects of warfarin, requiring closer monitoring of INR levels. Concomitant use with other CNS stimulants may lead to additive effects, increasing the risk of nervousness, tremor, or insomnia.

Missed dose

If a dose of Artvigil is missed, it should be taken as soon as remembered unless it is close to the time of the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule resumed. Doubling the dose to make up for a missed one is not recommended, as it may increase the risk of side effects such as insomnia or hypertension. Patients should maintain a consistent dosing routine to ensure optimal therapeutic effects.

Overdose

Symptoms of Artvigil overdose may include insomnia, restlessness, agitation, confusion, tachycardia, hypertension, and gastrointestinal distress. In severe cases, hallucinations or seizures may occur. There is no specific antidote for armodafinil overdose; management is supportive and symptomatic. Gastric lavage or administration of activated charcoal may be considered if ingestion was recent. Cardiovascular and mental status should be monitored closely in a medical facility. Patients or caregivers should seek immediate medical attention in case of suspected overdose.

Storage

Artvigil tablets should be stored at room temperature (15–30°C or 59–86°F) in a dry place, protected from light and moisture. Keep the medication in its original blister packaging until use to maintain stability. Do not store in bathrooms or near sinks. Keep out of reach of children and pets. Dispose of any unused or expired medication in accordance with local regulations, ideally through a medication take-back program.

Disclaimer

This information is intended for educational purposes only and does not constitute medical advice. Artvigil is a prescription medication and should be used only under the supervision of a qualified healthcare provider. Individual response to treatment may vary. Always follow the dosage and instructions provided by your prescribing physician. Do not initiate, adjust, or discontinue use without professional guidance. The manufacturer and distributor are not liable for any misuse or adverse outcomes resulting from the use of this product.

Reviews

Clinical studies and patient reports generally indicate high satisfaction with Artvigil for improving wakefulness and cognitive function. Users frequently note its long-lasting effects without significant crash, though some report initial side effects such as mild headache or insomnia that often subside. Healthcare professionals appreciate its favorable pharmacokinetic profile and lower abuse potential compared to traditional stimulants. However, individual experiences may vary, and it is essential that treatment be tailored and monitored by a healthcare provider to ensure safety and efficacy.