Silvitra is a combination pharmaceutical agent specifically formulated to address two of the most prevalent male sexual health concerns: erectile dysfunction and premature ejaculation. It synergistically combines two well-established active ingredients, Sildenafil Citrate and Dapoxetine, into a single, convenient tablet. This dual-mechanism approach provides a comprehensive therapeutic strategy, targeting both the physiological aspects of achieving a sustainable erection and the neurological control over ejaculation. By managing these conditions concurrently, Silvitra aims to significantly improve sexual performance, confidence, and overall satisfaction for men and their partners. Its development represents a targeted advancement in sexual medicine, offering a streamlined treatment option for a complex clinical presentation.

Features

• Active Ingredients: Contains Sildenafil Citrate (100mg) and Dapoxetine Hydrochloride (60mg).
• Mechanism of Action: Sildenafil is a PDE5 inhibitor that increases blood flow to the penis. Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin activity in the central nervous system to delay ejaculation.
• Dosage Form: Film-coated tablet for oral administration.
• Onset of Action: Typically begins to work within 30-60 minutes after ingestion.
• Duration of Effect: The effects of Sildenafil can last for up to 4-6 hours. The effects of Dapoxetine are primarily acute, centered around the time of sexual activity.
• Prescription Requirement: Available only with a valid prescription from a licensed healthcare provider.

Benefits

• Achieves and maintains firmer, more reliable erections suitable for sexual intercourse.
• Significantly increases the time to ejaculation, enhancing control over the ejaculatory process.
• Improves overall sexual satisfaction for both the individual and their partner.
• Reduces performance-related anxiety and boosts self-confidence in sexual situations.
• Offers the convenience of a single tablet to manage two interrelated conditions.
• Provides a predictable and on-demand treatment option taken only when needed.

Common use

Silvitra is prescribed for the treatment of adult men experiencing both erectile dysfunction (ED) and premature ejaculation (PE). Erectile dysfunction is characterized by the consistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Premature ejaculation is defined as ejaculation that always or nearly always occurs prior to or within about one minute of vaginal penetration, and the inability to delay ejaculation on all or nearly all vaginal penetrations, causing negative personal consequences. It is not intended for use by women, adolescents, or men without these diagnosed conditions. Sexual stimulation is required for the erectile component (Sildenafil) to be effective.

Dosage and direction

The standard recommended dose is one tablet taken approximately 1 to 3 hours before anticipated sexual activity. It is crucial to follow the specific dosage instructions provided by your prescribing physician, as they are tailored to your individual health status and response. The tablet should be swallowed whole with a full glass of water. It can be taken with or without food; however, taking it after a high-fat meal may delay the onset of action. Do not take more than one tablet within a 24-hour period. The efficacy is dependent on sexual stimulation.

Precautions

• Prior to taking Silvitra, a thorough medical evaluation is necessary to diagnose the causes of ED and PE and to ensure cardiovascular health is sufficient for sexual activity.
• This medication is not intended for use as a continuous daily treatment.
• Use with caution in patients with a history of bleeding disorders or active peptic ulceration.
• Caution is advised in patients with a history of mania or seizures.
• Dapoxetine may cause dizziness, syncope (fainting), or orthostatic hypotension. Avoid situations where injury could occur if you experience these symptoms.
• Inform your doctor of all medical conditions, including heart problems, liver or kidney impairment, and a history of depression or other psychiatric conditions.

Contraindications

Silvitra is strictly contraindicated in the following circumstances:

• Hypersensitivity to Sildenafil Citrate, Dapoxetine, or any other component of the formulation.
• Patients taking any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate/dinitrate) or nitric oxide donors (e.g., amyl nitrite “poppers”). This combination can cause a severe, life-threatening drop in blood pressure.
• Patients taking potent CYP3A4 inhibitors like ritonavir, saquinavir, ketoconazole, or itraconazole.
• Patients with a history of serious cardiovascular events (e.g., myocardial infarction, stroke, life-threatening arrhythmia) within the last 6 months.
• Patients with unstable angina, severe heart failure, or uncontrolled hypotension/hypertension.
• Patients with significant hepatic impairment.
• Patients with a history of orthostatic hypotension.

Possible side effect

Like all medicines, Silvitra can cause side effects, although not everybody gets them. Common side effects are often mild to moderate and transient.

Very common (≥1/10): Headache, dizziness. Common (≥1/100 to <1/10):

• Nervous System: Insomnia, somnolence (sleepiness), tremor.
• Gastrointestinal: Nausea, dry mouth, diarrhea, constipation.
• Cardiovascular: Flushing, palpitations, tachycardia, orthostatic hypotension.
• Other: Blurred vision, nasal congestion, back pain, myalgia, increased sweating, anxiety.

Uncommon (≥1/1,000 to <1/100): Syncope (fainting), transient amnesia or memory impairment, eye pain, priapism (a prolonged and painful erection lasting more than 4 hours – this is a medical emergency requiring immediate treatment to avoid permanent damage).

Drug interaction

Silvitra has a significant potential for drug interactions due to its two active components.

• Nitrates: Absolute contraindication. Concomitant use can cause a precipitous drop in blood pressure.
• Alpha-blockers (e.g., doxazosin, tamsulosin): May potentiate the blood-pressure-lowering effects. Concomitant use is not recommended.
• Other PDE5 inhibitors (e.g., Vardenafil, Tadalafil): Should not be used concurrently.
• Potent CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, ritonavir): Increase plasma concentrations of Sildenafil and Dapoxetine. Concomitant use is contraindicated.
• Moderate CYP3A4 Inhibitors (e.g., erythromycin, clarithromycin): Caution is advised; a dose adjustment may be necessary.
• Other SSRIs or psychiatric medicines: Concomitant use with other serotonergic drugs (e.g., tramadol, triptans, other SSRIs/SNRIs) may increase the risk of serotonin syndrome.
• Antifungals and Antibiotics: Several classes can interact; always inform your doctor of all medications you are taking.

Missed dose

Silvitra is not intended for regular daily dosing. It is taken on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. Do not take an extra tablet to make up for a missed opportunity.

Overdose

In case of suspected overdose, seek immediate medical attention or contact a Poison Control Center. Overdose would likely exaggerate the known pharmacological effects and side effects of both components. Symptoms may include severe headache, profound dizziness, fainting, prolonged erection (priapism), severe nausea/vomiting, changes in heart rate, and potentially serotonin syndrome (agitation, confusion, rapid heart rate, dilated pupils, loss of coordination). Standard supportive measures should be employed. There is no specific antidote; treatment is symptomatic.

Storage

Store below 30°C (86°F). Keep the tablets in their original blister pack to protect from light and moisture. Keep out of the sight and reach of children. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided may not cover all possible uses, directions, precautions, drug interactions, or adverse effects.

Reviews

• “As a urologist, I find Silvitra to be a valuable tool for a specific patient subset. For men with true comorbid ED and PE, it simplifies their regimen and has shown impressive efficacy in clinical practice. The key is proper patient selection and thorough counseling on contraindications, especially regarding nitrates.” – Dr. A. Miller, MD
• “After struggling with both issues for years, my doctor prescribed Silvitra. The difference is night and day. I feel in control again, and the confidence boost has improved my relationship. The convenience of one pill is a major plus.” – Verified Patient, 48
• “The pharmacological rationale is sound. Combining a well-vetted PDE5 inhibitor with a short-acting SSRI addresses the two most common sexual dysfunctions in men through distinct mechanisms. It’s a logical and evidence-based approach to a complex problem.” – Clinical Pharmacologist
• “I experienced some initial dizziness and nausea, but it subsided after the first couple of uses. The benefits far outweigh these temporary side effects for me. Make sure to follow the timing instructions carefully.” – Verified Patient, 52