Voveran SR (diclofenac sodium sustained release) is a prescription nonsteroidal anti-inflammatory drug (NSAID) specifically formulated for the long-term management of moderate to severe pain and inflammation associated with chronic musculoskeletal and joint disorders. Its advanced sustained-release technology ensures a steady plasma concentration, providing consistent therapeutic effect over a 24-hour period with a single daily dose. This makes it a cornerstone in treatment protocols for conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, offering patients a reliable option for improved functional mobility and quality of life.

Features

• Active ingredient: Diclofenac sodium (100mg per tablet)
• Formulation: Sustained-release (SR) gastro-resistant tablet
• Mechanism: Potent cyclooxygenase (COX-1 and COX-2) enzyme inhibition
• Pharmacokinetics: Designed for once-daily dosing with controlled release over 24 hours
• Bioavailability: Approximately 50-60% following oral administration
• Half-life: 12-15 hours in its sustained-release form
• Excretion: Primarily renal, with biliary excretion of metabolites

Benefits

• Provides continuous, around-the-clock relief from inflammatory pain and stiffness, reducing the frequency of dosing.
• Enhances patient compliance and convenience through a simple once-daily regimen.
• Improves joint mobility and functional capacity in chronic arthritic conditions.
• Effectively reduces local inflammation, edema, and tenderness at the site of musculoskeletal disorders.
• Supports long-term management of chronic pain with a well-established safety profile when used as directed.
• Minimizes peak-trough fluctuations in drug plasma levels, contributing to stable symptom control.

Common use

Voveran SR is primarily indicated for the symptomatic treatment of chronic inflammatory and degenerative forms of rheumatism, including rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also used in the management of acute musculoskeletal disorders such as periarticular conditions (e.g., bursitis, tendinitis), low back pain, and post-traumatic pain. Its use is reserved for conditions where prolonged anti-inflammatory and analgesic effects are required, and it is not suitable for the treatment of acute, short-term pain.

Dosage and direction

The recommended dosage for adults is one 100mg sustained-release tablet once daily, taken whole with a sufficient amount of fluid, preferably with or after food to minimize gastrointestinal irritation. The tablet must not be chewed, crushed, or broken, as this would disrupt the sustained-release mechanism. Dosage should be individualized to the lowest effective dose for the shortest duration possible. For elderly patients or those with mild to moderate renal impairment, a starting dose of one 75mg tablet may be considered. Treatment should be reviewed regularly by a healthcare professional.

Precautions

Use with caution in patients with a history of gastrointestinal disorders (e.g., ulcers, bleeding), cardiovascular disease, hypertension, renal or hepatic impairment, asthma, or bleeding diatheses. Periodic monitoring of renal function, liver enzymes, and blood pressure is advised during long-term therapy. Patients should be advised to avoid alcohol consumption and the use of other NSAIDs concurrently. Voveran SR may mask the signs of infection; careful observation is required in patients with concurrent infectious conditions.

Contraindications

Hypersensitivity to diclofenac, other NSAIDs, or any excipients in the formulation. Patients with active peptic ulceration, gastrointestinal bleeding, or perforation. Severe heart failure (NYHA Class IV), ischemic heart disease, peripheral arterial disease, or cerebrovascular disease. Third trimester of pregnancy. Severe hepatic or renal impairment. Established aspirin-induced asthma or urticaria.

Possible side effects

Common side effects (>1/100) include epigastric pain, nausea, diarrhea, dyspepsia, flatulence, and headache. Uncommon side effects (≥1/1,000 to <1/100) may include dizziness, rash, pruritus, increased liver enzymes, and peripheral edema. Rare but serious side effects (<1/1,000) include gastrointestinal ulceration or bleeding, hepatotoxicity, acute renal failure, bronchospasm, Stevens-Johnson syndrome, and anaphylactic reactions. Patients should seek immediate medical attention for signs of bleeding, allergic reactions, or symptoms of liver dysfunction.

Drug interaction

Concomitant use with other NSAIDs or aspirin increases the risk of gastrointestinal adverse events. May reduce the effect of antihypertensive agents and diuretics. Concurrent use with anticoagulants (e.g., warfarin) or antiplatelet agents increases bleeding risk. Caution with methotrexate (increased toxicity), ciclosporin (nephrotoxicity), lithium (elevated lithium levels), and quinolone antibiotics (increased seizure risk). Corticosteroids may exacerbate ulcer risk.

Missed dose

If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume the usual dosing schedule. Do not take a double dose to make up for a missed one.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, drowsiness, dizziness, tinnitus, or convulsions. Rarely, acute renal failure or respiratory depression may occur. There is no specific antidote; treatment is supportive and symptomatic. Gastric lavage and activated charcoal may be considered if presented early. Hemodialysis is not effective due to high protein binding.

Storage

Store at room temperature (15-30°C), in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider for diagnosis, treatment decisions, and personalized dosage recommendations. Do not initiate or discontinue therapy without medical supervision.

Reviews

Clinical studies and post-marketing surveillance indicate that Voveran SR is effective in reducing pain and improving physical function in patients with chronic inflammatory conditions. Many patients report significant improvement in daily activities and quality of life. However, individual responses may vary, and adherence to prescribed dosage and monitoring recommendations is crucial for optimal outcomes and risk management.