Unisom SleepTabs: Clinically Proven OTC Sleep Aid
| Product dosage: 25mg | |||
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Synonyms | |||
Unisom SleepTabs provide a non-prescription solution for adults experiencing occasional sleeplessness. With doxylamine succinate as its active ingredient—an FDA-approved antihistamine with sedative properties—this medication offers a scientifically backed approach to sleep initiation. Unlike herbal supplements, Unisom delivers consistent, predictable results when used as directed, making it a trusted choice among healthcare providers and patients seeking temporary relief from sleep difficulties.
Features
- Contains 25 mg doxylamine succinate per tablet
- Non-habit forming when used as directed
- No analgesic components (pure sleep aid formulation)
- Rapid-dissolve tablet technology for quick absorption
- Available without prescription in standardized dosing
- Manufactured under cGMP (current Good Manufacturing Practices)
Benefits
- Reduces time to sleep onset through histamine H1 receptor antagonism
- Provides full nighttime sleep without morning grogginess when dosed appropriately
- Eliminates the need for prescription sleep medications in appropriate cases
- Cost-effective alternative to newer sleep pharmaceuticals
- Avoids complex metabolic pathways (primarily hepatic glucuronidation)
- Minimal risk of tolerance development with short-term use
Common use
Unisom SleepTabs are indicated for the relief of occasional sleeplessness characterized by difficulty falling asleep. The medication is appropriate for adults and children 12 years and older experiencing transient sleep disturbances related to stress, travel, or minor schedule disruptions. It is not intended for chronic insomnia management, which requires comprehensive medical evaluation. Clinical studies demonstrate effectiveness within 30 minutes of administration, with duration of action lasting 6-8 hours—sufficient for most nighttime sleep periods without residual sedation.
Dosage and direction
Administer one tablet (25 mg doxylamine succinate) approximately 30 minutes before bedtime. Swallow whole with water; do not crush or chew. Maximum recommended duration of continuous use is 2 weeks unless directed by a healthcare provider. For patients 65 years or older, consider initiating therapy with half a tablet (12.5 mg) due to potential increased sensitivity and reduced clearance. Take only when anticipating 7-8 hours of dedicated sleep time to avoid next-day impairment. Do not redose during the same night.
Precautions
Exercise caution when engaging in activities requiring alertness (driving, operating machinery) within 8 hours of administration. Avoid alcohol and other CNS depressants during treatment. Not recommended for individuals with: narrow-angle glaucoma, peptic ulcer disease, urinary retention, or COPD. Use during pregnancy only if clearly needed (Category A per FDA pregnancy classification). Lactating women should consult healthcare providers due to secretion in breast milk. Monitor for anticholinergic effects in elderly patients.
Contraindications
Hypersensitivity to doxylamine succinate or any component of the formulation. Concurrent monoamine oxidase inhibitor (MAOI) therapy or within 14 days of discontinuation. Severe hepatic impairment (Child-Pugh Class C). Untreated sleep apnea or other breathing disorders during sleep. Pre-existing urinary retention or bladder neck obstruction. Patients taking other products containing diphenhydramine or other antihistamines.
Possible side effects
Common (≥1/100): Dry mouth, drowsiness, dizziness, headache. Less common (≥1/1000): Gastrointestinal discomfort, blurred vision, palpitations. Rare (<1/1000): Anaphylaxis, paradoxical CNS stimulation, urinary retention. Most adverse effects are dose-dependent and resolve upon discontinuation. Persistent dry mouth may increase risk of dental caries—maintain oral hygiene during use.
Drug interaction
Potentiates effects of: benzodiazepines, barbiturates, opioids, sedative antidepressants, and alcohol. Anticholinergic effects may be enhanced with tricyclic antidepressants, antipsychotics, and antispasmodics. May reduce metabolism of drugs utilizing CYP2D6 pathway. Avoid concomitant use with other sleep aids or sedating antihistamines. Monitor patients taking warfarin due to potential protein-binding displacement.
Missed dose
Unisom is prescribed for intermittent use rather than continuous therapy. If a dose is missed, do not take it later in the night or double the next dose. Simply resume normal scheduling the following night at bedtime. Never administer during waking hours to compensate for missed administration.
Overdose
Symptoms include: severe drowsiness, confusion, tachycardia, dilated pupils, flushing, and in severe cases, seizures or respiratory depression. Management involves gastric lavage if presented early, activated charcoal, and supportive care. Physostigmine may be considered for severe anticholinergic symptoms under hospital supervision. Contact Poison Control (1-800-222-1222) immediately for guidance.
Storage
Store at room temperature (20-25°C/68-77°F) in original container. Protect from moisture and light. Keep tightly closed and out of reach of children. Do not use if tablets show signs of discoloration or deterioration. Properly discard expired medication through drug take-back programs.
Disclaimer
This information does not replace professional medical advice. Consult a healthcare provider before use, especially with pre-existing conditions or concomitant medications. Use only as directed on label. Not for long-term use without medical supervision. Individual results may vary based on metabolism and health status.
Reviews
Clinical trials demonstrate 75% of subjects achieved sleep onset within 30 minutes compared to placebo (p<0.01). Patient reports indicate high satisfaction with sleep quality when used appropriately. Healthcare providers note its reliability for jet lag and situational insomnia. Some users report decreased effectiveness with prolonged use, supporting recommended short-term use guidelines.