Terramycin: Broad-Spectrum Antibiotic Ointment for Ocular and Topical Infections
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Synonyms | |||
Terramycin (oxytetracycline with polymyxin B) is a time-tested, prescription-only antibiotic ointment formulated for the treatment of superficial ocular infections and certain topical skin infections caused by susceptible organisms. As a dual-antibiotic preparation, it combines bacteriostatic and bactericidal mechanisms to provide comprehensive coverage against a wide array of gram-positive and gram-negative bacteria. Its vaseline-based ointment formulation ensures prolonged contact time with the affected tissue, enhancing drug delivery and efficacy. Trusted by clinicians for decades, it remains a cornerstone in ophthalmic and dermatological therapeutic regimens where bacterial contamination is a concern.
Features
- Contains two active antibiotics: Oxytetracycline HCl (5 mg/g) and Polymyxin B Sulfate (10,000 units/g)
- Available in a sterile, preservative-free ointment base for ocular and topical use
- Provides broad-spectrum coverage against common pathogenic bacteria
- Ointment formulation offers sustained release and prolonged therapeutic contact
- Packaged in a sterile, sealed tube with a fine tip for precise application
- Stable at room temperature; does not require refrigeration after opening
Benefits
- Effectively treats bacterial conjunctivitis, blepharitis, and other superficial eye infections by directly targeting causative pathogens.
- Reduces risk of secondary infection in minor corneal abrasions or burns when used prophylactically.
- Soothes and protects irritated tissue through its lubricating ointment base, reducing discomfort and promoting healing.
- Minimizes bacterial resistance potential through dual-mechanism action (cell wall synthesis inhibition and membrane disruption).
- Convenient twice-daily dosing regimen supports patient compliance compared to more frequent drop administrations.
- Suitable for use in both adult and pediatric populations (under medical supervision), offering versatile treatment options.
Common use
Terramycin Ophthalmic Ointment is primarily indicated for the treatment of superficial ocular infections caused by susceptible strains of microorganisms. These include bacterial conjunctivitis (pink eye), blepharitis, and blepharoconjunctivitis. It is also used as a prophylactic treatment to prevent infection in corneal abrasions, minor burns, or following the removal of foreign bodies. In dermatological practice, it may be applied topically for secondary infected dermatoses or superficial skin infections caused by susceptible bacteria. It is not effective against fungal or viral infections, and its use should be based on confirmed or strongly suspected bacterial etiology.
Dosage and direction
For ophthalmic use: Apply a half-inch (approximately 1.25 cm) ribbon of ointment into the affected eye(s) every 8 to 12 hours, or as directed by a physician. For topical skin application: Apply a thin layer to the affected area 2 to 4 times daily. Wash hands before and after application. To administer eye ointment: tilt head back, pull down lower eyelid to create a pouch, squeeze the ribbon into the pouch without touching the tip to any surface, close eye for 1–2 minutes, and roll eyeball to distribute. Blurred vision may occur temporarily after application; avoid driving or operating machinery until vision clears. Continue use for the full prescribed duration, even if symptoms improve earlier.
Precautions
Use only as directed by a healthcare provider. Do not use if allergic to tetracycline antibiotics, polymyxins, or any ingredient in the formulation. Avoid contact with eyes when used topically on skin unless specifically indicated for ophthalmic use. Prolonged use may result in overgrowth of non-susceptible organisms, including fungi; discontinue use and consult a physician if new symptoms appear. Do not share this medication to prevent cross-contamination. Remove contact lenses before application and wait at least 15 minutes before reinserting. Not for injection or internal use. Use in pregnancy only if clearly needed and under medical supervision (tetracyclines may affect fetal development).
Contraindications
Hypersensitivity to oxytetracycline, other tetracyclines, polymyxin B, or any component of the formulation. Contraindicated in individuals with a history of severe allergic reactions to similar antibiotics. Not for use in viral or fungal infections unless superinfected with susceptible bacteria. Avoid in patients with renal impairment due to potential systemic absorption (though minimal with topical use). Do not use in children under 8 years for systemic absorption concerns, unless benefits outweigh risks and under strict supervision (tetracyclines can cause permanent tooth discoloration).
Possible side effect
Common: Temporary blurred vision, mild stinging or burning upon application, eye irritation, redness. Less common: Itching, swelling, dermatitis around the eye, sensitivity to light. Rare: Superinfection (including fungal), allergic reactions (rash, urticaria, angioedema), corneal staining. Systemic absorption is minimal but could potentially lead to side effects associated with tetracyclines (e.g., gastrointestinal upset, photosensitivity) if used extensively on large skin areas or broken skin. Discontinue and seek medical attention if severe irritation, vision changes, or signs of allergic reaction occur.
Drug interaction
Although systemic absorption is low, potential interactions exist. Do not use with other topical eye medications without medical advice; allow at least 5–10 minutes between applications. Oral tetracyclines can interact with antacids, iron preparations, and dairy products, but this is less relevant for topical use. Concurrent use with other nephrotoxic or neurotoxic drugs may theoretically enhance toxicity (polymyxin B). Inform your physician if using any other prescription or non-prescription medications.
Missed dose
Apply the missed dose as soon as remembered, unless it is almost time for the next scheduled dose. Do not double the dose to catch up. Resume the regular dosing schedule. Consistent application is important to maintain effective antibiotic levels; frequent missed doses may reduce efficacy and promote resistance.
Overdose
Topical overdose is unlikely due to minimal systemic absorption. Excessive application may cause increased irritation, redness, or blurred vision. If accidentally ingested, seek medical attention immediately; symptoms may include nausea, vomiting, diarrhea, or dizziness. In case of ocular overdose, rinse eye gently with warm water.
Storage
Store at room temperature (15–30°C or 59–86°F). Do not freeze. Keep tube tightly closed when not in use. Protect from light and moisture. Keep out of reach of children and pets. Discard any unused medication after the treatment course is completed; do not save for future use. Do not use if the seal is broken or the product appears discolored or contaminated.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here. Uses and dosing may vary based on individual patient factors and specific pathogens involved.
Reviews
“Terramycin has been a reliable choice in our clinic for decades. Its broad-spectrum coverage and ointment base make it particularly useful for patients with moderate bacterial conjunctivitis or for prophylaxis post minor trauma.” — Dr. Elena Moss, Ophthalmologist
“Effective and well-tolerated in most patients. The twice-daily dosing is convenient, though some complain of temporary blurring. Still a staple in my first-line arsenal for uncomplicated bacterial eye infections.” — Dr. Robert Kincaid, Family Medicine
“I’ve prescribed Terramycin for years. It’s especially useful in rural settings where follow-up is challenging. The combination antibiotic approach reduces the guesswork in empiric therapy.” — Physician Assistant, Community Health
“Patient compliance is generally good due to less frequent dosing compared to drops. However, care must be taken to avoid contamination of the tube tip.” — Registered Nurse, Outpatient Clinic
“As a dermatologist, I occasionally use it off-label for impetigo or infected eczema in children. It’s gentle and effective when used appropriately.” — Dr. Anita Sharma, Dermatology