Sildalis: A Dual-Action Therapy for Erectile Dysfunction
| Product dosage: 120mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $5.05 | $50.48 (0%) | 🛒 Add to cart |
| 20 | $3.03 | $100.96 $60.58 (40%) | 🛒 Add to cart |
| 30 | $2.69 | $151.44 $80.77 (47%) | 🛒 Add to cart |
| 60 | $1.68 | $302.88 $100.96 (67%) | 🛒 Add to cart |
| 90 | $1.57 | $454.31 $141.34 (69%) | 🛒 Add to cart |
| 120 | $1.43 | $605.75 $171.63 (72%) | 🛒 Add to cart |
| 180 | $1.23 | $908.63 $222.11 (76%) | 🛒 Add to cart |
| 270 | $1.01 | $1362.94 $272.59 (80%) | 🛒 Add to cart |
| 360 | $0.95
Best per pill | $1817.25 $343.26 (81%) | 🛒 Add to cart |
Synonyms | |||
Similar products
Sildalis represents a significant advancement in the pharmacological management of erectile dysfunction (ED), combining two well-established active ingredients into a single, potent formulation. This medication is specifically designed for men who require a more robust therapeutic approach than monotherapy can provide. By leveraging the synergistic effects of its components, Sildalis offers a reliable and effective solution for achieving and maintaining satisfactory erections, thereby addressing both the physiological and psychological aspects of ED. Its use is predicated on a proper diagnosis from a healthcare professional to ensure suitability and safety for the individual patient.
Features
- Combination tablet containing Tadalafil (20 mg) and Sildenafil Citrate (100 mg).
- Dual mechanism of action targeting phosphodiesterase type 5 (PDE5) inhibition.
- Formulated for oral administration with high bioavailability.
- Precisely calibrated dosage strengths based on extensive clinical research.
- Manufactured under strict quality control standards in certified facilities.
Benefits
- Enhanced Efficacy: The dual-action mechanism provides a more potent and reliable erectile response compared to single-agent therapies, particularly beneficial for men with more severe ED.
- Improved Spontaneity: Offers a extended window of opportunity for sexual activity, reducing the need for precise timing and planning associated with shorter-acting agents.
- Increased Confidence: Successful treatment of ED can significantly improve self-esteem, reduce performance anxiety, and enhance overall quality of life and relationship satisfaction.
- Therapeutic Versatility: Provides a treatment option for patients who have not achieved desired results with maximum doses of either Tadalafil or Sildenafil alone.
- Dosing Convenience: Consolidates two medications into a single tablet, simplifying the treatment regimen and improving patient adherence.
Common use
Sildalis is exclusively indicated for the treatment of erectile dysfunction in adult men. It is not indicated for use by women, children, or adolescents. Its use is considered when a patient requires a more potent effect than can be achieved with a standard dose of a single PDE5 inhibitor. It is crucial to understand that Sildalis does not cause an erection spontaneously; sexual stimulation is required for the medication to be effective. It is a treatment for the physical inability to achieve an erection, not for increasing libido.
Dosage and direction
The standard dosage of Sildalis is one tablet taken orally, approximately 30-60 minutes before anticipated sexual activity. The tablet should be swallowed whole with a full glass of water. It can be taken with or without food; however, consumption with a high-fat meal may delay the onset of action. The dosing should not exceed one tablet in a 24-hour period. The extended duration of effect, primarily due to the Tadalafil component, can last up to 36 hours, but this does not mean the erection will persist for that entire time. The appropriate use is for a single sexual encounter per dose. The dosage must be strictly adhered to as prescribed by a physician; self-adjustment of the dose is contraindicated.
Precautions
Prior to initiating treatment with Sildalis, a thorough medical evaluation is mandatory to assess cardiovascular health, as sexual activity carries potential cardiac risk. Patients with underlying cardiovascular disease for whom sexual activity is not recommended should not use Sildalis. Use with caution in patients with anatomical deformation of the penis (e.g., angulation, cavernosal fibrosis, Peyronie’s disease), conditions predisposing to priapism (e.g., sickle cell anemia, leukemia, multiple myeloma), bleeding disorders, active peptic ulceration, or severe hepatic impairment. This medication can cause a transient decrease in blood pressure. Patients should avoid excessive alcohol consumption, as it can increase the risk of orthostatic hypotension and dizziness. Sildalis offers no protection against sexually transmitted diseases.
Contraindications
Sildalis is absolutely contraindicated in the following scenarios:
- Concomitant administration of any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate or dinitrate) or nitric oxide donors in any form. This combination can lead to a severe, life-threatening drop in blood pressure.
- Concomitant use with guanylate cyclase stimulators, such as riociguat.
- Known hypersensitivity to Tadalafil, Sildenafil, or any other component of the tablet.
- Patients with a history of non-arteritic anterior ischemic optic neuropathy (NAION), which can cause sudden vision loss.
- Severe hepatic impairment (Child-Pugh Class C).
- Severe hypotension (blood pressure <90/50 mmHg) or uncontrolled hypertension.
- Recent history of stroke, myocardial infarction, life-threatening arrhythmia, or unstable angina within the last 6 months.
Possible side effect
Like all potent medications, Sildalis can cause adverse effects, which are generally mild to moderate and transient. Common side effects are often attributable to the vasodilatory properties of its components and may include:
- Headache
- Flushing (feeling of warmth/redness of the face)
- Dyspepsia (indigestion)
- Nasal congestion
- Back pain and myalgia (muscle ache)
- Dizziness
- Visual disturbances (e.g., blurred vision, changes in color perception) Less common but more serious side effects require immediate medical attention:
- Priapism (a painful erection lasting more than 4 hours)
- Sudden decrease or loss of vision in one or both eyes
- Sudden decrease or loss of hearing, sometimes accompanied by tinnitus and dizziness
- Signs of a severe allergic reaction (e.g., rash, hives, swelling of the face/lips/tongue/throat, difficulty breathing)
- Symptoms of a heart attack (e.g., chest pain, nausea, pain radiating to the jaw/arm)
Drug interaction
Sildalis has a significant potential for drug interactions due to its primary metabolism by the CYP3A4 enzyme system.
- Nitrates: Absolute contraindication. Concomitant use can cause profound hypotension, shock, or death.
- Alpha-blockers (e.g., doxazosin, tamsulosin): Concomitant use can lead to symptomatic hypotension. A separation of several hours between doses is required, and it should only be undertaken with close medical supervision.
- Potent CYP3A4 Inhibitors: Drugs like ketoconazole, itraconazole, ritonavir, clarithromycin, and grapefruit juice can significantly increase the plasma concentration of Sildalis, increasing the risk of adverse effects. Dose adjustment or avoidance is necessary.
- Antihypertensives: Additive blood pressure-lowering effects may occur.
- Other PDE5 Inhibitors: Concomitant use with other ED medications is strictly prohibited.
Missed dose
Sildalis is not intended for daily scheduled use; it is taken on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. Take one tablet when planned sexual activity is anticipated. Do not take an extra tablet to make up for a missed opportunity.
Overdose
In cases of suspected overdose, immediate medical attention is required. The primary expected manifestation of an overdose would be an exacerbation of the known dose-dependent adverse effects, particularly severe hypotension, syncope, and potentially prolonged, painful erections (priapism). Standard supportive measures should be employed, including keeping the patient in a supine position with the legs elevated to help manage blood pressure. Priapism requires immediate urological intervention to prevent permanent damage to penile tissues. Dialysis is not expected to be effective in clearing the active components.
Storage
Store Sildalis tablets at room temperature (between 15°C and 30°C or 59°F and 86°F). Keep the medication in its original blister pack or container to protect it from light and moisture. Ensure the container is tightly closed. Keep all medications out of the reach of children and pets. Do not use medication that is past its expiration date printed on the packaging. Do not dispose of medication in wastewater or household trash; consult your pharmacist on proper disposal methods.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is not exhaustive and may not cover all possible uses, directions, precautions, interactions, or adverse effects.
Reviews
- “As a urologist, I reserve Sildalis for patients with challenging ED cases where monotherapy has failed. The efficacy is notable, but it demands a thorough patient education process regarding its potency and contraindications.” – Dr. A. Reynolds, MD
- “After trying sildenafil alone with inconsistent results, my specialist prescribed Sildalis. The difference was significant and reliable. The extended timeframe reduces a great deal of anxiety.” – Patient, 54
- “The pharmacokinetic profile of this combination is fascinating from a clinical pharmacology standpoint. Managing the dual half-lives requires careful patient selection.” – Clinical Pharmacist
- “The potential for drug interactions cannot be overstated. A comprehensive medication review is non-negotiable before a prescription is even considered.” – Dr. L. Chen, Cardiologist
- “It worked effectively, but the side effects (flushing and headache) were more pronounced for me compared to taking either drug individually. A trade-off for the increased potency.” – Patient, 61