Poxet: Clinically Proven Premature Ejaculation Management
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Poxet represents a significant advancement in the pharmacological management of premature ejaculation (PE), offering men a reliable and effective solution to improve sexual health and intimate relationships. This selective serotonin reuptake inhibitor (SSRI) is specifically formulated to address the neurobiological mechanisms underlying ejaculatory control, providing a targeted approach that goes beyond behavioral techniques. With a well-established efficacy and safety profile supported by clinical data, Poxet enables physicians to offer evidence-based treatment, helping patients achieve greater sexual satisfaction and confidence. Its role in a comprehensive management plan underscores a modern understanding of sexual medicine.
Features
- Active Pharmaceutical Ingredient: Dapoxetine hydrochloride
- Available Strengths: 30 mg and 60 mg film-coated tablets
- Pharmacological Class: Selective Serotonin Reuptake Inhibitor (SSRI)
- Rapid Onset of Action: Designed for on-demand use, not daily administration
- Short Elimination Half-Life: Approximately 1.5–2 hours, minimizing next-day residual effects
- Bioavailability: Approximately 42% following oral administration
- Prescription-Only Medication: Requires medical consultation and diagnosis
Benefits
- Significantly increases intravaginal ejaculatory latency time (IELT), allowing for more controlled and satisfying sexual experiences.
- Improves perceived control over ejaculation and reduces distress related to sexual performance, enhancing overall sexual satisfaction for both partners.
- Provides a flexible, on-demand dosing regimen that integrates seamlessly into sexual activity without the need for daily medication.
- Supported by extensive clinical trial data demonstrating efficacy and a favorable benefit-risk profile in diverse patient populations.
- Complements psychosexual therapy and counseling as part of a holistic treatment approach for premature ejaculation.
- Helps restore confidence and reduce anxiety associated with sexual performance, contributing to improved relationship dynamics.
Common use
Poxet is indicated for the treatment of premature ejaculation (PE) in adult men aged 18–64 years. Premature ejaculation is defined clinically as a persistent or recurrent pattern of ejaculation occurring within approximately one minute of vaginal penetration (lifelong PE) or a clinically significant reduction in latency time, often to three minutes or less (acquired PE), and associated with negative personal consequences such as distress, bother, frustration, and/or avoidance of sexual intimacy. It is intended for patients who meet diagnostic criteria for PE and for whom pharmacological intervention is deemed appropriate after a thorough medical and sexual history assessment. Poxet is not indicated for use in women, adolescents, or men without a formal diagnosis of PE.
Dosage and direction
The recommended starting dose is 30 mg, taken orally approximately 1–3 hours before anticipated sexual activity. Based on efficacy and tolerability, the dose may be increased to 60 mg. Poxet should not be taken more than once within a 24-hour period. The tablet should be swallowed whole with at least one full glass of water; it may be taken with or without food, although high-fat meals may delay absorption. Patients should be advised that sexual stimulation is still required for the medication to be effective; it does not automatically induce erection or ejaculation. Dose adjustment is recommended in patients with renal or hepatic impairment, and use is not recommended in patients with severe renal or hepatic impairment.
Precautions
Prior to initiating treatment, a comprehensive medical evaluation should be conducted to confirm the diagnosis of PE and rule out other sexual dysfunctions or underlying physiological conditions. Use with caution in patients with a history of mood disorders, including depression or anxiety, and monitor for emerging symptoms. Caution is advised in patients with orthostatic hypotension, cardiovascular disease, or conditions that could be exacerbated by vasovagal episodes. Patients should be advised to avoid alcohol while taking Poxet, as it may increase the risk of adverse events such as dizziness, syncope, or hypotension. Poxet is not recommended for use with other SSRIs, SNRIs, or monoamine oxidase inhibitors (MAOIs).
Contraindications
Poxet is contraindicated in patients with known hypersensitivity to dapoxetine or any excipients in the formulation. It is contraindicated in patients with significant cardiac conditions such as heart failure (NYHA Class II–IV), conduction abnormalities (e.g., sick sinus syndrome, Wolff-Parkinson-White syndrome), or significant ischemic heart disease. Concomitant use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy is contraindicated due to the risk of serotonin syndrome. It is also contraindicated in patients with moderate or severe hepatic impairment. Concomitant use with thioridazine or other CYP2D6 inhibitors that may significantly increase dapoxetine exposure is not recommended.
Possible side effects
The most commonly reported adverse reactions are mild to moderate in intensity and often diminish with continued use. These include nausea (20–30%), dizziness (10–15%), headache (10–12%), diarrhea (5–7%), insomnia (5–6%), and fatigue (4–5%). Less frequently, orthostatic hypotension, syncope, blurred vision, and increased sweating may occur. Although rare, serious side effects such as serotonin syndrome (characterized by agitation, hallucinations, tachycardia, and hyperthermia) and syncope have been reported. Patients should be advised to discontinue use and seek medical attention if they experience symptoms suggestive of a serious adverse reaction.
Drug interaction
Dapoxetine is primarily metabolized by multiple CYP enzymes, including CYP3A4, CYP2D6, and others. Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin) is contraindicated. Concurrent use with moderate CYP3A4 inhibitors or strong CYP2D6 inhibitors should be approached with caution and may require dose reduction. Concomitant administration with other serotonergic drugs (e.g., SSRIs, SNRIs, tricyclic antidepressants, triptans, tramadol) increases the risk of serotonin syndrome. Potentiation of orthostatic hypotension may occur with alpha-blockers, nitrates, and other antihypertensive agents. Use with phosphodiesterase type 5 inhibitors (e.g., sildenafil) has not been systematically studied and is not recommended.
Missed dose
Poxet is intended for on-demand use rather than continuous daily administration; therefore, the concept of a “missed dose” does not apply in the conventional sense. If a patient forgets to take Poxet prior to sexual activity, the tablet should be skipped for that occasion. Patients should not take a double dose to make up for a missed administration. The next dose may be taken as needed, following the recommended dosing guidelines (not more than once in 24 hours). Patients should be educated on the importance of timing the dose 1–3 hours before anticipated sexual activity for optimal effect.
Overdose
In the event of overdose, supportive measures should be instituted, and the patient should be monitored closely. Symptoms of overdose may include serotonergic effects such as agitation, confusion, sweating, tachycardia, and in severe cases, serotonin syndrome. Cardiovascular effects including hypotension and syncope may also occur. There is no specific antidote for dapoxetine overdose. Treatment should focus on managing symptoms: activated charcoal may be administered if ingestion was recent, and ECG monitoring is advised in cases of significant overdose. Hemodialysis is unlikely to be effective due to high protein binding and large volume of distribution.
Storage
Store Poxet tablets at room temperature (15–30°C or 59–86°F) in a dry place, protected from light and moisture. Keep the medication in its original blister pack until the time of use to maintain stability and prevent degradation. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging. Proper disposal of unused or expired medication should be conducted in accordance with local regulations, preferably through a medicine take-back program.
Disclaimer
This information is intended for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any new medication or making changes to your treatment plan. Do not disregard or delay seeking professional medical advice based on information contained in this document. The efficacy and safety of Poxet may vary based on individual patient factors, and only a licensed healthcare professional can determine its appropriateness for a specific individual.
Reviews
Clinical studies and post-marketing surveillance data consistently demonstrate that Poxet is effective in prolonging IELT and improving patient-reported outcomes related to control over ejaculation and sexual satisfaction. In randomized controlled trials, men taking Poxet 30 mg and 60 mg experienced significant improvements in IELT compared to placebo. Patient satisfaction surveys indicate that a majority of users report improved confidence and reduced distress associated with sexual activity. Some users note mild and transient side effects, primarily nausea and dizziness, which often decrease with continued use. Overall, Poxet is regarded by clinicians as a valuable option within a multimodal approach to managing premature ejaculation.