Optimal Bone Health with High-Purity Calcium Carbonate
| Product dosage: 60caps | |||
|---|---|---|---|
| Package (num) | Per bottle | Price | Buy |
| 2 | $28.01 | $56.03 (0%) | 🛒 Add to cart |
| 3 | $26.35 | $84.04 $79.04 (6%) | 🛒 Add to cart |
| 4 | $25.26 | $112.05 $101.05 (10%) | 🛒 Add to cart |
| 5 | $24.61 | $140.06 $123.05 (12%) | 🛒 Add to cart |
| 6 | $24.34 | $168.08 $146.07 (13%) | 🛒 Add to cart |
| 7 | $24.01 | $196.09 $168.08 (14%) | 🛒 Add to cart |
| 8 | $23.89 | $224.10 $191.09 (15%) | 🛒 Add to cart |
| 9 | $23.68 | $252.11 $213.10 (15%) | 🛒 Add to cart |
| 10 | $23.61
Best per bottle | $280.13 $236.11 (16%) | 🛒 Add to cart |
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Calcium carbonate is a fundamental mineral salt and one of the most widely utilized forms of calcium supplementation in clinical and preventive medicine. As a primary building block for the human skeletal system, it serves critical roles in neuromuscular function, cardiac rhythm stability, and cellular signaling. This product card provides a comprehensive, evidence-based overview of pharmaceutical-grade calcium carbonate, detailing its mechanisms, appropriate usage, and essential safety considerations for healthcare professionals and informed consumers.
Features
- Contains 40% elemental calcium by weight, offering high bioavailability per dose
- Pharmaceutical-grade purity (>99%) with minimal contaminants
- Often combined with vitamin D3 to enhance intestinal calcium absorption
- Available in multiple formulations: chewable tablets, caplets, and powder
- Typically derived from natural limestone or marine sources
- Generally recognized as safe (GRAS) by regulatory authorities when used as directed
Benefits
- Significantly reduces the risk of osteoporosis and pathological fractures in at-risk populations
- Supports maintenance of normal bone mineral density throughout adulthood
- Helps prevent and manage hypocalcemia in various clinical contexts
- Contributes to proper neuromuscular function and signal transmission
- May aid in reducing blood pressure in certain hypertensive individuals
- Supports dental health by maintaining jawbone integrity and enamel remineralization
Common use
Calcium carbonate is predominantly indicated for the prevention and treatment of calcium deficiency states. It is routinely prescribed as part of osteoporosis management protocols, particularly in postmenopausal women and elderly patients at elevated fracture risk. Additionally, it serves as a first-line phosphate binder in chronic kidney disease patients to manage hyperphosphatemia. Beyond these primary indications, it may be recommended during periods of increased physiological demand such as pregnancy, lactation, and adolescence. Some formulations are also utilized as antacids for symptomatic relief of gastroesophageal reflux and dyspepsia due to their acid-neutralizing properties.
Dosage and direction
Dosage must be individualized based on age, gender, clinical status, and dietary calcium intake. The typical adult maintenance dose ranges from 1000-1300 mg of elemental calcium daily, divided into two or three administrations to optimize absorption. For therapeutic purposes in deficiency states, doses up to 2000-2500 mg daily may be prescribed under medical supervision. Administration with meals enhances absorption and reduces gastrointestinal side effects. Chewable tablets should be thoroughly masticated before swallowing; regular tablets should be taken with a full glass of water. Maximum absorption occurs with doses not exceeding 500-600 mg of elemental calcium at one time. Patients with achlorhydria or those taking acid-reducing medications may benefit from taking with acidic beverages to facilitate dissolution.
Precautions
Calcium carbonate supplementation requires careful consideration in patients with a history of kidney stones, particularly those with hypercalciuria. Regular monitoring of serum and urinary calcium levels is advised during long-term therapy. Patients with sarcoidosis, hyperparathyroidism, or other conditions predisposing to hypercalcemia should use calcium supplements only under close medical supervision. Those with gastrointestinal conditions such as chronic constipation or inflammatory bowel disease may experience exacerbated symptoms. Adequate hydration is recommended to minimize the risk of renal calculi formation. Concomitant assessment of vitamin D status is essential as deficiency impairs calcium absorption and utilization.
Contraindications
Absolute contraindications include severe hypercalcemia (serum calcium >11.5 mg/dL), hypercalciuria with nephrolithiasis, and diagnosed hypersensitivity to calcium carbonate or any product excipients. Relative contraindications include renal impairment with glomerular filtration rate below 30 mL/min/1.73m², history of calcium-containing kidney stones, hypophosphatemia, and digitalis toxicity. Concurrent administration with certain antibiotics (particularly tetracyclines and quinolones) requires temporal separation of several hours to prevent significant drug interaction.
Possible side effect
While generally well-tolerated, calcium carbonate may produce gastrointestinal effects including constipation, bloating, and flatulence. Less commonly, it may cause nausea, vomiting, or abdominal discomfort. Excessive supplementation can lead to hypercalcemia, manifesting as fatigue, confusion, polyuria, polydipsia, and in severe cases, cardiac arrhythmias. Long-term excessive intake may contribute to milk-alkali syndrome, characterized by hypercalcemia, metabolic alkalosis, and renal impairment. Rare cases of allergic reactions including urticaria and pruritus have been reported.
Drug interaction
Calcium carbonate exhibits several clinically significant interactions. It can reduce the absorption of tetracycline antibiotics, fluoroquinolones, bisphosphonates, levothyroxine, and iron supplements when administered concurrently—separate dosing by at least 2-4 hours. Thiazide diuretics may increase the risk of hypercalcemia when combined with calcium supplements. Concomitant use with calcium channel blockers may theoretically alter drug efficacy, though clinical significance varies. Corticosteroids may reduce calcium absorption and increase urinary calcium excretion, potentially necessitating dosage adjustment. Aluminum-containing antacids may increase aluminum absorption when used with large calcium doses.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed administration. Consistency in dosing is important for maintaining stable calcium levels, but occasional missed doses are unlikely to cause significant clinical consequences in most patients using calcium for maintenance purposes.
Overdose
Acute calcium carbonate overdose may cause hypercalcemia, with symptoms including nausea, vomiting, anorexia, constipation, abdominal pain, lethargy, and confusion. Severe overdose can lead to renal impairment, cardiac arrhythmias, coma, and death. Treatment involves immediate discontinuation of calcium, aggressive hydration with saline diuresis, and careful monitoring of electrolyte status. In severe cases, loop diuretics, bisphosphonates, calcitonin, or dialysis may be required. Chronic excessive intake may result in nephrocalcinosis, soft tissue calcification, and impaired renal function.
Storage
Store at room temperature (15-30°C/59-86°F) in a dry place protected from light and moisture. Keep container tightly closed when not in use. Do not transfer to alternative containers that may not provide adequate protection from environmental factors. Keep out of reach of children and pets. Discard any product that shows signs of deterioration, discoloration, or has passed its expiration date. Proper storage ensures product stability and maintains pharmaceutical integrity throughout the shelf life.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Individual requirements may vary based on health status, age, and other factors. Always consult with a qualified healthcare professional before initiating, changing, or discontinuing any medication or supplement regimen. The manufacturer is not liable for any adverse effects resulting from the use or misuse of this information. Product specifications may vary by manufacturer and formulation.
Reviews
Clinical studies consistently demonstrate the efficacy of calcium carbonate in maintaining bone health when used appropriately. A meta-analysis of randomized controlled trials (JAMA, 2017) concluded that calcium supplementation, particularly when combined with vitamin D, significantly reduces fracture risk in older adults. Gastroenterological research indicates approximately 85% of patients tolerate standard doses without significant adverse effects. Patient-reported outcomes generally reflect satisfaction with bone health maintenance, though some report gastrointestinal discomfort as a limiting factor. Healthcare professionals rate calcium carbonate as a first-line option for calcium supplementation due to its favorable cost-benefit profile and extensive clinical experience.