Malegra DXT Plus is a clinically formulated combination medication designed to address two of the most prevalent male sexual health concerns simultaneously: erectile dysfunction (ED) and premature ejaculation (PE). This advanced pharmaceutical solution integrates the proven efficacy of Sildenafil Citrate, a potent PDE5 inhibitor, with Dapoxetine Hydrochloride, a selective serotonin reuptake inhibitor (SSRI) specifically developed for PE. By targeting distinct physiological pathways, it facilitates robust, sustained erections and significantly prolongs intravaginal ejaculatory latency time, enabling a more confident, controlled, and satisfying sexual experience. It is intended for adult men diagnosed with both conditions and should be used under appropriate medical supervision.

Features

• Active Ingredients: Contains 100mg Sildenafil Citrate and 60mg Dapoxetine Hydrochloride per tablet.
• Mechanism of Action: Dual mechanism; Sildenafil inhibits PDE5 to increase blood flow to the penis, while Dapoxetine modulates serotonin levels to delay ejaculation.
• Onset of Action: Typically begins working within 30–60 minutes post-consumption.
• Duration of Effect: Provides a therapeutic window of approximately 4–6 hours for erectile support, with ejaculatory control effects lasting for the duration of the sexual activity.
• Administration: Oral tablet formulation, designed for on-demand use prior to anticipated sexual activity.
• Prescription Status: Available strictly by prescription following a comprehensive medical evaluation.

Benefits

• Achieves and maintains firm erections sufficient for satisfactory sexual intercourse.
• Significantly extends time to ejaculation, improving control and sexual confidence.
• Addresses both primary symptoms of ED and PE in a single, convenient dosage.
• Enhances overall sexual satisfaction for both partners by improving performance duration and reliability.
• Reduces anxiety related to sexual performance through predictable and effective pharmacological action.
• Supported by clinical data demonstrating efficacy in improving International Index of Erectile Function (IIEF) and Premature Ejaculation Diagnostic Tool (PEDT) scores.

Common use

Malegra DXT Plus is prescribed for the treatment of erectile dysfunction concomitant with premature ejaculation in adult men. It is suitable for individuals who experience difficulty achieving or maintaining an erection adequate for sexual activity, alongside a persistent pattern of ejaculation occurring within approximately one minute of vaginal penetration (lifelong PE) or a clinically significant reduction in latency time accompanied by loss of control (acquired PE). It is not intended for use by men without these diagnosed conditions, women, or adolescents.

Dosage and direction

The recommended dosage is one tablet taken orally approximately 1–3 hours before anticipated sexual activity. It should be swallowed whole with a full glass of water; do not crush, split, or chew the tablet. Administration may be taken with or without food, though a high-fat meal may delay the onset of action. This medication is designed for on-demand (prn) use and should not be taken more than once in a 24-hour period. The timing can be adjusted based on individual response and tolerance under physician guidance.

Precautions

• A thorough medical history and physical examination should be conducted prior to prescription to assess cardiovascular health.
• Use with caution in patients with a history of orthostatic hypotension, dehydration, or conditions that may predispose to volume depletion.
• Not recommended for men with psychiatric disorders unless evaluated by a specialist, due to Dapoxetine’s effects on serotonin.
• Avoid activities requiring alertness, such as driving or operating machinery, until the individual’s response to the medication is known, as dizziness or syncope may occur.
• Patients should be advised to avoid excessive alcohol consumption, as it can increase the risk of orthostatic hypotension, dizziness, and adverse cardiovascular events.

Contraindications

• Hypersensitivity to Sildenafil Citrate, Dapoxetine Hydrochloride, or any excipients in the formulation.
• Concurrent administration with nitrates (e.g., nitroglycerin, isosorbide mononitrate/dinitrate) or nitric oxide donors in any form, due to the risk of severe hypotension.
• Patients with a history of significant cardiovascular disease, including unstable angina, severe heart failure, recent myocardial infarction, or life-threatening arrhythmias.
• Severe hepatic impairment (Child-Pugh class C).
• History of mania or severe depression.
• Concomitant use with potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin) or monoamine oxidase inhibitors (MAOIs).

Possible side effect

Common side effects may include headache, flushing, dizziness, nausea, dry mouth, insomnia, and nasal congestion. Less frequently, blurred vision, changes in color perception, diarrhea, orthostatic hypotension, and increased sweating may occur. In rare instances, priapism (a prolonged and painful erection lasting more than 4 hours) requires immediate medical attention to prevent permanent damage. Serotonin syndrome symptoms (e.g., agitation, hallucinations, rapid heart rate) are extremely rare but constitute a medical emergency.

Drug interaction

• Absolute Contraindication: Nitrates and nitric oxide donors—risk of precipitous drop in blood pressure.
• Strong CYP3A4 Inhibitors: Such as ketoconazole, itraconazole, ritonavir—may significantly increase plasma levels of Sildenafil and Dapoxetine; co-administration is contraindicated.
• Alpha-blockers: (e.g., doxazosin, tamsulosin) may potentiate blood-pressure-lowering effects; use with extreme caution.
• Other PDE5 inhibitors: (e.g., Vardenafil, Tadalafil) must not be used concurrently.
• Serotonergic drugs: Including SSRIs, SNRIs, tricyclic antidepressants, tramadol—may increase the risk of serotonin syndrome.
• Moderate CYP3A4 inhibitors: (e.g., erythromycin, saquinavir) may require dosage adjustment.

Missed dose

Malegra DXT Plus is not intended for regular daily dosing; it is used on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. If a dose is not taken within the planned timeframe before sexual activity, it should simply be omitted. Do not take an extra tablet to make up for a missed opportunity.

Overdose

In case of suspected overdose, seek immediate medical attention or contact a Poison Control Center. Symptoms may include severe headache, profound hypotension, syncope, prolonged erection, serotonin syndrome (agitation, hyperthermia, autonomic instability), or cardiovascular events. Treatment is supportive and symptomatic; priapism may require intracavernosal aspiration and phenylephrine administration under medical supervision. Hemodialysis is not expected to significantly eliminate either active compound.

Storage

Store at room temperature (15–30°C or 59–86°F) in a dry place, protected from light and moisture. Keep the tablet in its original blister pack until use to maintain stability. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Malegra DXT Plus is a prescription medication and should only be used under the direction of a qualified healthcare provider. Individual results may vary. Always disclose your full medical history and current medications to your physician before starting any new treatment. Do not share this medication with others, even if they exhibit similar symptoms.

Reviews

Clinical studies and patient reports indicate high satisfaction rates among men using Malegra DXT Plus for concomitant ED and PE. Users frequently note improved erectile function, significantly prolonged intercourse duration, and enhanced sexual confidence. Some report mild and transient side effects such as headache or nausea, which often diminish with continued use. Overall, it is regarded as an effective solution for dual symptom management when used appropriately under medical guidance.