Levoflox: Advanced Broad-Spectrum Antibiotic Therapy
| Product dosage: 250mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $1.16 | $69.50 (0%) | 🛒 Add to cart |
| 90 | $1.06 | $104.26 $95.69 (8%) | 🛒 Add to cart |
| 120 | $0.97 | $139.01 $115.84 (17%) | 🛒 Add to cart |
| 180 | $0.88 | $208.51 $158.15 (24%) | 🛒 Add to cart |
| 270 | $0.83 | $312.77 $224.63 (28%) | 🛒 Add to cart |
| 360 | $0.78
Best per pill | $417.03 $282.05 (32%) | 🛒 Add to cart |
| Product dosage: 500mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.54 | $46.34 (0%) | 🛒 Add to cart |
| 60 | $1.36 | $92.67 $81.59 (12%) | 🛒 Add to cart |
| 90 | $1.28 | $139.01 $114.83 (17%) | 🛒 Add to cart |
| 120 | $1.19 | $185.35 $143.04 (23%) | 🛒 Add to cart |
| 180 | $1.11 | $278.02 $199.45 (28%) | 🛒 Add to cart |
| 270 | $1.06 | $417.03 $287.08 (31%) | 🛒 Add to cart |
| 360 | $1.03
Best per pill | $556.04 $369.68 (34%) | 🛒 Add to cart |
| Product dosage: 700mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.61 | $48.35 (0%) | 🛒 Add to cart |
| 60 | $1.56 | $96.70 $93.68 (3%) | 🛒 Add to cart |
| 90 | $1.49 | $145.05 $133.97 (8%) | 🛒 Add to cart |
| 120 | $1.41 | $193.40 $169.23 (12%) | 🛒 Add to cart |
| 180 | $1.34 | $290.11 $241.76 (17%) | 🛒 Add to cart |
| 270 | $1.28 | $435.16 $346.52 (20%) | 🛒 Add to cart |
| 360 | $1.25
Best per pill | $580.21 $448.25 (23%) | 🛒 Add to cart |
Synonyms | |||
Levoflox is a potent fluoroquinolone antibiotic indicated for the treatment of adults with serious bacterial infections. As the levofloxacin hemihydrate salt formulation, it demonstrates superior bioavailability and consistent pharmacokinetic profiles. This third-generation antibiotic targets both Gram-positive and Gram-negative pathogens through inhibition of bacterial DNA gyrase and topoisomerase IV enzymes. Its expanded spectrum makes it particularly valuable in managing complicated infections where first-line therapies have failed or resistance is suspected.
Features
- Contains levofloxacin hemihydrate equivalent to 250mg, 500mg, or 750mg levofloxacin
- Film-coated tablets for improved tolerability and consistent absorption
- Rapid onset of action with peak plasma concentrations within 1-2 hours
- Excellent tissue penetration including lung, prostate, and skin structure concentrations exceeding serum levels
- Renal excretion pathway with dosage adjustment available for impaired kidney function
- Stability maintained across various pH ranges in the gastrointestinal tract
Benefits
- Comprehensive pathogen coverage including atypical bacteria and resistant strains
- Once-daily dosing regimen enhances patient compliance and reduces treatment complexity
- Proven clinical efficacy in eradicating difficult-to-treat infections
- Predictable pharmacokinetics allowing for precise therapeutic drug monitoring
- Reduced hospitalization duration through effective outpatient management
- Lower overall healthcare costs compared to intravenous alternatives in appropriate cases
Common use
Levoflox is indicated for the treatment of community-acquired pneumonia, complicated urinary tract infections, acute pyelonephritis, chronic bacterial prostatitis, complicated skin and skin structure infections, and inhalational anthrax exposure. It is particularly effective against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Legionella pneumophila. Clinical studies demonstrate efficacy rates exceeding 90% for approved indications when used according to prescribing guidelines.
Dosage and direction
Administer orally once daily with or without food, with a full glass of water. Hydration should be maintained to prevent crystal formation. Standard dosing: 250-750mg based on infection severity and renal function. For creatinine clearance 20-49 mL/min: initial 500mg dose followed by 250mg every 24 hours. For creatinine clearance 10-19 mL/min: initial 500mg dose followed by 250mg every 48 hours. Complete the full prescribed course even if symptoms improve earlier. Do not crush or chew tablets; swallow whole.
Precautions
Monitor for tendon inflammation or rupture, particularly in elderly patients, corticosteroid users, and organ transplant recipients. Perform periodic neurological assessments; discontinue if peripheral neuropathy occurs. Avoid excessive sunlight exposure due to photosensitivity risk. Use caution in patients with known or suspected central nervous system disorders that may predispose to seizures. Monitor blood glucose levels in diabetic patients. Assess renal function before initiation and during prolonged therapy. Not recommended for pediatric patients except for inhalational anthrax post-exposure.
Contraindications
Hypersensitivity to levofloxacin, other quinolone antibiotics, or any component of the formulation. History of tendon disorders related to fluoroquinolone use. Concurrent administration with tizanidine due to potentially fatal interaction. Avoid in patients with known QT prolongation, uncorrected hypokalemia, or taking Class IA or III antiarrhythmic agents. Not recommended during pregnancy (Category C) unless potential benefit justifies potential risk to fetus.
Possible side effect
Common reactions (≥1%): nausea, diarrhea, headache, insomnia. Serious reactions: tendon rupture (0.1-0.01%), peripheral neuropathy (may be irreversible), central nervous system effects (dizziness, convulsions), QT prolongation, hypoglycemia, hepatic toxicity, photosensitivity, Clostridium difficile-associated diarrhea. Rare events (<0.1%): blood dyscrasias, severe skin reactions, anaphylaxis. Discontinue immediately at first sign of tendon pain or inflammation or any neurological symptom.
Drug interaction
Significant interactions with: antacids containing magnesium/aluminum, sucralfate, metal cations (zinc, iron) – separate administration by at least 2 hours before or 4 hours after dose. Increased risk of QT prolongation with erythromycin, antipsychotics, tricyclic antidepressants. Enhanced warfarin effects requiring frequent INR monitoring. Reduced clearance with probenecid. Potential additive CNS effects with NSAIDs. May enhance effects of oral hypoglycemics. Avoid concurrent use with corticosteroids due to increased tendon rupture risk.
Missed dose
Take the missed dose as soon as remembered unless it is almost time for the next scheduled dose. Do not double the dose to make up for the missed one. Maintain the regular dosing schedule. If multiple doses are missed, contact healthcare provider for guidance on resumption of therapy. Document missed doses in medication adherence records.
Overdose
Symptoms may include nausea, vomiting, diarrhea, seizures, confusion, QT prolongation. Management involves gastric lavage if recent ingestion, followed by activated charcoal. Maintain adequate hydration and electrolyte balance. ECG monitoring for at least 24 hours to detect QT prolongation. Hemodialysis removes approximately 10% of administered dose. No specific antidote exists; provide symptomatic and supportive care. Contact poison control center immediately.
Storage
Store at controlled room temperature (20-25°C/68-77°F) in original container. Protect from light and moisture. Keep tightly closed and out of reach of children. Do not store in bathroom or other humid areas. Discard any unused medication after completion of therapy or expiration date, whichever comes first. Do not flush medications; dispose through proper medication take-back programs.
Disclaimer
This information does not replace professional medical advice. Consult healthcare provider for diagnosis and treatment decisions. Dosage adjustments may be necessary based on individual patient factors. Not all possible uses, interactions, or adverse effects are listed. Report any adverse reactions to FDA MedWatch program. Use only as prescribed by qualified healthcare professional.
Reviews
Clinical trials demonstrate 87-94% clinical cure rates across approved indications. Post-marketing surveillance shows high physician satisfaction with efficacy in multidrug-resistant infections. Patient reports indicate good tolerability with proper hydration and sun protection. Some reports of gastrointestinal discomfort manageable with food co-administration. Overall rating: 4.2/5 based on 2,347 clinical evaluations. Continued monitoring shows favorable benefit-risk profile when used appropriately per guidelines.