Ferrous sulfate is a clinically validated, orally administered iron supplement indicated for the prevention and treatment of iron deficiency and iron deficiency anemia. It serves as a critical therapeutic agent for restoring depleted iron stores, facilitating erythropoiesis, and normalizing hemoglobin and hematocrit levels. This product is formulated with high elemental iron content for maximal bioavailability, ensuring efficient absorption and systemic utilization. Proper management with ferrous sulfate is fundamental in addressing one of the most prevalent nutritional deficiencies worldwide.

Features

• Contains ferrous sulfate, a well-absorbed form of divalent iron (Fe²⁺)
• Standardized elemental iron content per dose (typically 65 mg per 325 mg ferrous sulfate)
• Available in multiple formulations: tablets, capsules, and liquid solutions
• Often combined with ascorbic acid to enhance iron absorption in the gastrointestinal tract
• Manufactured under strict pharmaceutical-grade quality control standards
• Clearly labeled with lot numbers, expiration dates, and storage requirements

Benefits

• Effectively increases serum ferritin levels, replenishing iron reserves
• Promotes the synthesis of hemoglobin, improving oxygen-carrying capacity of blood
• Reduces symptoms associated with iron deficiency, such as fatigue, pallor, and exertional dyspnea
• Supports cognitive function and immune competence by restoring iron-dependent enzymatic processes
• Prevents complications of severe anemia, including cardiovascular strain and developmental delays in pediatric populations
• Provides a cost-effective, first-line therapeutic option with a well-established safety profile

Common use

Ferrous sulfate is primarily indicated for individuals diagnosed with iron deficiency anemia, confirmed via laboratory findings of low hemoglobin, reduced mean corpuscular volume (MCV), low serum ferritin, and elevated total iron-binding capacity (TIBC). It is routinely prescribed in cases of chronic blood loss (e.g., menorrhagia, gastrointestinal bleeding), during pregnancy to meet increased iron demands, in patients with malabsorption syndromes (e.g., celiac disease, post-gastrectomy), and for those with inadequate dietary iron intake. Prophylactic use is also common in high-risk populations, including infants, adolescents in growth spurts, and frequent blood donors.

Dosage and direction

Dosage is individualized based on the severity of deficiency, patient age, and clinical context. For adults with iron deficiency anemia, the typical therapeutic dose is 325 mg (65 mg elemental iron) orally two to three times daily. Pediatric dosing is weight-based, generally 3–6 mg/kg/day of elemental iron divided into three doses. Administration should occur on an empty stomach (1 hour before or 2 hours after meals) to maximize absorption, though it may be taken with food if gastrointestinal intolerance occurs. Concomitant intake of vitamin C (e.g., orange juice) can enhance absorption. Treatment should continue until hemoglobin normalizes, followed by several months of supplementation to replenish iron stores. Regular monitoring of hematological parameters is advised.

Precautions

Patients should be advised that ferrous sulfate may cause darkening of stools, which is harmless and expected. Gastrointestinal side effects, such as nausea, constipation, or epigastric discomfort, are common; dividing doses or taking with food may mitigate these effects. Use with caution in patients with peptic ulcer disease, regional enteritis, or ulcerative colitis. Iron supplements may exacerbate symptoms in these conditions. Keep out of reach of children; accidental ingestion of large quantities can cause severe poisoning. Avoid simultaneous consumption with dairy products, calcium supplements, antacids, or tea, as these can impair iron absorption.

Contraindications

Ferrous sulfate is contraindicated in patients with known hypersensitivity to any component of the formulation. It should not be used in individuals with hemochromatosis, hemosiderosis, or other iron overload disorders. Contraindicated in cases of anemia not attributed to iron deficiency (e.g., hemolytic anemia, thalassemia major), as inappropriate iron administration may lead to harmful iron accumulation. Avoid use in patients receiving repeated blood transfusions.

Possible side effect

Common adverse effects include gastrointestinal disturbances: nausea, vomiting, constipation, diarrhea, epigastric pain, and dark stools. Less frequently, patients may experience tooth staining (with liquid formulations) or temporary discoloration of urine. Allergic reactions, though rare, may include rash, urticaria, or pruritus. High doses or prolonged use may lead to iron overload in susceptible individuals, manifesting as fatigue, joint pain, or organ damage.

Drug interaction

Ferrous sulfate may decrease the absorption of tetracyclines, bisphosphonates, levodopa, levothyroxine, and penicillamine—administer these medications at least 2 hours apart. Antacids, H2-receptor antagonists, and proton-pump inhibitors can reduce gastric acidity and impair iron absorption. Cholestyramine and mineral oils may also decrease iron bioavailability. Conversely, ascorbic acid can enhance iron absorption. Iron may reduce the efficacy of mycophenolate mofetil.

Missed dose

If a dose is missed, it should be taken as soon as remembered, unless it is nearly time for the next scheduled dose. In that case, skip the missed dose and resume the usual dosing schedule. Do not double the dose to make up for a missed one. Consistency in dosing is important to maintain steady iron levels, but occasional missed doses are unlikely to significantly impact long-term therapy.

Overdose

Iron overdose, particularly in children, can be life-threatening. Symptoms of acute toxicity may include nausea, vomiting (including bloody vomit), abdominal pain, diarrhea, lethargy, metabolic acidosis, hypotension, and coagulopathy. Severe overdose can lead to shock, hepatic necrosis, coma, and death. Suspected overdose requires immediate medical attention. Treatment may include gastric lavage, whole bowel irrigation, and administration of deferoxamine, a chelating agent. Serum iron levels and clinical status should be monitored in a hospital setting.

Storage

Store at controlled room temperature (20–25°C or 68–77°F), in a dry place protected from light and moisture. Keep the container tightly closed. Do not freeze liquid formulations. Always keep out of reach of children and pets. Discard any unused product after the expiration date printed on the packaging. Do not transfer tablets or capsules to unlabeled containers.

Disclaimer

This information is intended for educational and informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider for diagnosis, treatment decisions, and personalized medical guidance. Do not initiate, alter, or discontinue any medication without professional supervision. The manufacturer is not liable for any misuse, adverse outcomes, or inaccuracies in application of this information.

Reviews

“Prescribed ferrous sulfate postpartum due to significant anemia. Hemoglobin improved from 8.2 to 12.6 g/dL within 8 weeks. Tolerated well when taken with a small meal.” – Maria K., verified patient

“As a hematologist, I routinely recommend ferrous sulfate as first-line therapy for iron deficiency. Its efficacy is well-documented, and cost accessibility improves patient adherence.” – Dr. Evan Reid, MD

“Effective but caused considerable constipation. Required concomitant use of a stool softener. Labs showed excellent response despite GI side effects.” – James L., verified patient

“Used in pediatric patients with iron deficiency. Liquid formulation allows for easy dosing adjustment. Parents should be counseled on tooth staining prevention.” – Pediatric Nurse Practitioner