Clarinex: Advanced Relief for Year-Round Allergy Symptoms
| Product dosage: 5mg | |||
|---|---|---|---|
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| 60 | $0.86 | $51.40 (0%) | 🛒 Add to cart |
| 90 | $0.73 | $77.10 $65.51 (15%) | 🛒 Add to cart |
| 120 | $0.67 | $102.80 $80.63 (22%) | 🛒 Add to cart |
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| 270 | $0.57 | $231.31 $154.20 (33%) | 🛒 Add to cart |
| 360 | $0.55
Best per pill | $308.41 $197.54 (36%) | 🛒 Add to cart |
Synonyms | |||
Clarinex (desloratadine) is a prescription antihistamine specifically formulated to provide long-lasting, non-drowsy relief from allergic rhinitis and chronic idiopathic urticaria. As a potent metabolite of loratadine, it offers enhanced efficacy with a favorable safety profile, making it a trusted choice among healthcare providers for managing both seasonal and perennial allergies. Its selective peripheral H1-receptor antagonism ensures targeted symptom control without central nervous system depression, supporting improved quality of life for allergy sufferers.
Features
- Active ingredient: desloratadine 5 mg
- Available in tablet, orally disintegrating tablet, and syrup formulations
- 24-hour duration of action with once-daily dosing
- Rapid onset of relief, often within 1–3 hours post-administration
- Minimal cytochrome P450 metabolism, reducing potential for drug interactions
- Sugar-free and dye-free syrup option for pediatric and sensitive patients
Benefits
- Provides comprehensive relief from sneezing, runny nose, itchy/watery eyes, and itching of the nose or throat
- Effectively reduces hive size and itching associated with chronic urticaria
- Maintains alertness and cognitive function with minimal sedative effects
- Supports adherence through convenient once-daily dosing regimen
- Suitable for long-term management of persistent allergy symptoms
- Improves sleep quality and daytime productivity by controlling nighttime allergy symptoms
Common use
Clarinex is primarily indicated for the relief of nasal and non-nasal symptoms of allergic rhinitis (seasonal and perennial) in adults and children 6 months and older. It is also approved for the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in patients 6 months and older. Healthcare providers may prescribe it off-label for other histamine-mediated conditions based on clinical judgment.
Dosage and direction
Adults and adolescents (12+ years): 5 mg orally once daily
Children (6–11 years): 2.5 mg (½ tablet or 2.5 mL syrup) once daily
Children (12 months–5 years): 1.25 mg (¼ tablet or 1.25 mL syrup) once daily
Infants (6–11 months): 1 mg (2 mL syrup) once daily
Tablets should be swallowed whole with water. Orally disintegrating tablets must be placed on the tongue immediately after opening the blister. May be taken with or without food. Dosage adjustment may be necessary in hepatic impairment.
Precautions
Use with caution in patients with renal impairment (CrCl <30 mL/min) or hepatic impairment. While Clarinex demonstrates minimal sedative effects, patients should exercise caution when engaging in activities requiring mental alertness until individual response is established. Pregnancy Category C: use only if potential benefit justifies potential risk to fetus. Excretion in human breast milk is probable—consider alternative feeding options during therapy.
Contraindications
Hypersensitivity to desloratadine, loratadine, or any component of the formulation. Contraindicated in patients with severe renal impairment (not on dialysis) or severe hepatic impairment without dosage adjustment. Orally disintegrating tablets contain phenylalanine and are contraindicated in patients with phenylketonuria.
Possible side effects
Most common adverse reactions (≥2% and greater than placebo):
- Headache (6%)
- Dry mouth (3%)
- Fatigue (2%)
- Pharyngitis (2%)
- Dizziness (2%)
- Somnolence (2%)
- Nausea (2%)
- Myalgia (2%)
Rare but serious side effects include tachycardia, hypersensitivity reactions (rash, urticaria, angioedema), and elevated liver enzymes. Discontinue immediately if severe reactions occur.
Drug interaction
No clinically significant interactions with ketoconazole, erythromycin, or azithromycin. Theoretical interactions with CNS depressants (alcohol, barbiturates, benzodiazepines) may potentiate sedation. Use caution with P-glycoprotein inhibitors. No meaningful interactions with warfarin observed in clinical studies.
Missed dose
If a dose is missed, take it as soon as remembered. If it is near the time of the next dose, skip the missed dose and resume regular dosing schedule. Do not double the dose to catch up.
Overdose
Symptoms may include drowsiness, tachycardia, and headache. There is no specific antidote. Gastric lavage may be considered if administered soon after ingestion. Provide supportive therapy including vital sign monitoring. Hemodialysis is unlikely to be beneficial due to high protein binding.
Storage
Store at 20–25°C (68–77°F). Excursions permitted to 15–30°C (59–86°F). Keep blister packages sealed until use. Protect from moisture. Store syrup in original container at room temperature—do not freeze. Keep all medications out of reach of children.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting or changing any medication regimen. Individual responses to medication may vary. Only a licensed medical professional can determine the appropriate treatment for specific medical conditions.
Reviews
“After struggling with year-round allergies that impacted my sleep and work performance, Clarinex provided consistent relief without the drowsiness I experienced with other antihistamines. My quality of life has significantly improved.” - Maria K., verified patient
“As an allergist, I’ve prescribed Clarinex for over a decade with excellent results. Its predictable pharmacokinetics and minimal interaction profile make it particularly valuable for patients on multiple medications.” - Dr. Evan R., MD, Allergy Specialist
“Pediatric patients tolerate the syrup formulation well, and parents appreciate the once-daily dosing. It’s become a first-line option in my practice for children with persistent allergic symptoms.” - Dr. Lisa T., Pediatrician