Celebrex: Targeted Relief for Osteoarthritis and Rheumatoid Arthritis
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $0.82 | $49.49 (0%) | 🛒 Add to cart |
| 90 | $0.71 | $74.23 $63.62 (14%) | 🛒 Add to cart |
| 120 | $0.64 | $98.97 $76.75 (22%) | 🛒 Add to cart |
| 180 | $0.58 | $148.46 $105.03 (29%) | 🛒 Add to cart |
| 270 | $0.55 | $222.68 $148.46 (33%) | 🛒 Add to cart |
| 360 | $0.53
Best per pill | $296.91 $190.87 (36%) | 🛒 Add to cart |
| Product dosage: 200mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.41 | $42.42 (0%) | 🛒 Add to cart |
| 60 | $0.99 | $84.83 $59.58 (30%) | 🛒 Add to cart |
| 90 | $0.85 | $127.25 $76.75 (40%) | 🛒 Add to cart |
| 120 | $0.78 | $169.66 $93.92 (45%) | 🛒 Add to cart |
| 180 | $0.72 | $254.50 $130.28 (49%) | 🛒 Add to cart |
| 270 | $0.67 | $381.74 $180.77 (53%) | 🛒 Add to cart |
| 360 | $0.65
Best per pill | $508.99 $234.30 (54%) | 🛒 Add to cart |
Synonyms
| |||
Celebrex (celecoxib) is a prescription nonsteroidal anti-inflammatory drug (NSAID) specifically formulated as a selective cyclooxygenase-2 (COX-2) inhibitor. It is indicated for the management of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain. Unlike traditional NSAIDs, which non-selectively inhibit both COX-1 and COX-2 enzymes, Celebrex provides anti-inflammatory and analgesic effects while potentially reducing the risk of certain gastrointestinal adverse events associated with non-selective inhibition. Its mechanism offers a valuable option for patients requiring long-term anti-inflammatory therapy with a tailored safety profile.
Features
- Active ingredient: Celebrex contains celecoxib as its sole active pharmaceutical ingredient.
- Formulation: Available in capsule form for oral administration, with strengths including 50 mg, 100 mg, 200 mg, and 400 mg.
- Pharmacological class: Classified as a selective COX-2 inhibitor, a subclass of NSAIDs.
- Prescription status: Available by prescription only, requiring medical supervision for use.
- Patent and manufacturer: Originally developed by G.D. Searle & Company (now part of Pfizer Inc.); multiple generic versions are also available.
- Onset of action: Demonstrates analgesic and anti-inflammatory effects within hours of administration, with peak plasma concentrations reached approximately 3 hours post-dose.
Benefits
- Provides effective reduction of pain and inflammation associated with chronic arthritic conditions.
- Minimizes gastrointestinal irritation compared to non-selective NSAIDs, due to its COX-2 selectivity.
- Supports improved joint function and mobility, enhancing quality of life for patients with degenerative joint diseases.
- Offers convenient once- or twice-daily dosing, supporting adherence to long-term treatment regimens.
- Reduces stiffness and swelling in affected joints, facilitating daily activities and physical function.
- Serves as an alternative for patients intolerant to other NSAIDs or requiring gastroprotective strategies.
Common use
Celebrex is commonly prescribed for the management of osteoarthritis and rheumatoid arthritis in adults. It is also used for the relief of acute pain, such as that associated with menstrual cramps (primary dysmenorrhea), and for the treatment of ankylosing spondylitis. In clinical practice, it is often selected for patients who have a history of gastrointestinal intolerance to non-selective NSAIDs or who are at increased risk for GI complications. Its use is generally reserved for situations where the anti-inflammatory and analgesic benefits outweigh potential cardiovascular and gastrointestinal risks.
Dosage and direction
For osteoarthritis: The recommended dose is 200 mg per day, administered as a single dose or as 100 mg twice daily. For rheumatoid arthritis: The recommended dose is 100 mg to 200 mg twice daily. For acute pain or primary dysmenorrhea: The recommended initial dose is 400 mg, followed by an additional 200 mg dose if needed on the first day. On subsequent days, the recommended dose is 200 mg twice daily as needed. For ankylosing spondylitis: The recommended dose is 200 mg daily in single or divided doses. If no effect is observed after 6 weeks, a trial of 400 mg daily may be considered. Dosage should be individualized to the lowest effective dose for the shortest duration consistent with treatment goals. Celebrex should be taken with a full glass of water, and may be administered with or without food. Patients should follow their healthcare provider’s instructions precisely and not adjust dosage without consultation.
Precautions
Patients should be advised to use Celebrex at the lowest effective dose for the shortest duration possible. Cardiovascular risk may increase with prolonged use; patients with cardiovascular disease or risk factors should be closely monitored. Gastrointestinal bleeding, ulceration, and perforation can occur at any time during use, without warning symptoms. Celebrex can lead to new hypertension or worsening of pre-existing hypertension; blood pressure should be monitored during treatment. Fluid retention and edema have been reported; caution is advised in patients with fluid retention, heart failure, or hypertension. Serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have been reported; treatment should be discontinued at the first appearance of skin rash or mucosal lesions. Renal toxicity has been observed; patients with impaired renal function, heart failure, or liver dysfunction, and those taking diuretics or ACE inhibitors, should use Celebrex with caution. Avoid use in patients with severe hepatic impairment (Child-Pugh Class C).
Contraindications
Celebrex is contraindicated in patients with known hypersensitivity to celecoxib. It should not be used in patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients. Celebrex is contraindicated in the setting of coronary artery bypass graft (CABG) surgery. It is also contraindicated in patients with a history of gastrointestinal bleeding or active peptic ulcer disease.
Possible side effects
Common adverse reactions (≥2%) include headache, dyspepsia, upper respiratory tract infection, diarrhea, sinusitis, abdominal pain, and nausea. Serious side effects may include cardiovascular thrombotic events (such as myocardial infarction and stroke), gastrointestinal bleeding, ulceration, and perforation, hepatotoxicity, hypertension, heart failure, renal injury, anaphylactic reactions, serious skin reactions, and hematologic toxicity (such as anemia). Patients should seek immediate medical attention for signs of allergic reactions (e.g., difficulty breathing, swelling of the face or throat), chest pain, weakness on one side of the body, slurred speech, black or bloody stools, vomiting blood, skin rash, unexplained weight gain, or swelling.
Drug interaction
Celebrex may interact with other medications, including:
- Aspirin: Concomitant use may increase the risk of GI bleeding.
- Anticoagulants (e.g., warfarin): Celebrex may enhance the anticoagulant effect, increasing the risk of bleeding.
- ACE inhibitors, angiotensin II receptor blockers (ARBs), and diuretics: Celebrex may reduce the antihypertensive effect and promote sodium and fluid retention.
- Lithium: Celebrex may increase lithium plasma levels.
- Fluconazole: Concomitant use may increase celecoxib plasma concentrations due to inhibition of CYP2C9.
- Other NSAIDs: Avoid concomitant use with other NSAIDs, as it may increase the risk of GI toxicity.
- SSRIs and SNRIs: May increase the risk of bleeding when used with Celebrex. Patients should inform their healthcare provider of all medications, including over-the-counter drugs and herbal supplements, before starting Celebrex.
Missed dose
If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped and the regular dosing schedule resumed. Doubling the dose to make up for a missed one is not recommended.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, coma, or anaphylaxis. There is no specific antidote for celecoxib overdose. Management should involve supportive and symptomatic care, including monitoring of vital signs and GI protection. Hemodialysis is not expected to be effective in removing celecoxib due to its high protein binding.
Storage
Celebrex capsules should be stored at room temperature, between 20°C to 25°C (68°F to 77°F), in a dry place. They should be kept in their original container, tightly closed, and protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here. Individual patient responses to Celebrex may vary, and only a healthcare professional can determine the appropriate therapy based on a patient’s specific health profile.
Reviews
Clinical studies and patient reports indicate that Celebrex is effective in reducing pain and improving function in many individuals with osteoarthritis and rheumatoid arthritis. Patients often note significant relief from joint stiffness and discomfort, with some appreciating the reduced gastrointestinal side effects compared to traditional NSAIDs. However, experiences vary; some users report inadequate pain relief or adverse effects such as headache or mild digestive issues. Long-term user satisfaction often depends on individual response, comorbid conditions, and adherence to prescribed dosing. Healthcare providers generally regard Celebrex as a useful option within the NSAID class, particularly for patients with a focus on GI tolerability, while emphasizing the need for ongoing monitoring of cardiovascular and renal parameters.