Beclomethasone: Advanced Anti-Inflammatory Relief for Respiratory Conditions
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| Product dosage: 2.5mg | |||
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Synonyms | |||
Similar products
Beclomethasone is a potent corticosteroid medication designed to manage and prevent symptoms of various respiratory conditions through targeted anti-inflammatory action. As an inhaled or nasal formulation, it delivers localized treatment directly to affected airways and nasal passages, minimizing systemic exposure while maximizing therapeutic benefits. This medication represents a cornerstone in maintenance therapy for asthma and allergic rhinitis, offering patients sustained symptom control and improved quality of life when used as prescribed under medical supervision.
Features
- Potent glucocorticoid receptor agonist with high anti-inflammatory efficacy
- Available in metered-dose inhaler (MDI), dry powder inhaler (DPI), and nasal spray formulations
- Microfine particle technology for optimal pulmonary and nasal deposition
- Hydrofluoroalkane (HFA) propellant in modern inhalers (ozone-friendly)
- Rapid onset of action with effects typically noticeable within 1-2 days of regular use
- Low oral bioavailability (<20%) due to extensive first-pass metabolism
- Multiple strength options (40 mcg, 50 mcg, 80 mcg, 100 mcg, 200 mcg per actuation)
Benefits
- Significantly reduces airway inflammation and mucosal edema in respiratory tissues
- Prevents asthma exacerbations and reduces emergency medication requirements
- Improves lung function parameters (FEV1, PEFR) in persistent asthma
- Decreases nasal congestion, sneezing, and rhinorrhea in allergic rhinitis
- Enhances overall quality of life by enabling normal daily activities
- Reduces frequency and severity of respiratory symptoms with regular use
Common use
Beclomethasone is primarily indicated for the prophylactic management of bronchial asthma in patients requiring regular corticosteroid therapy. It is not intended for relief of acute bronchospasm but rather for long-term control of airway inflammation. The nasal formulation is approved for the treatment of seasonal and perennial allergic rhinitis symptoms. Off-label uses may include eosinophilic esophagitis (swallowed inhaler) and certain dermatological conditions, though these applications require specialist supervision. The medication is typically prescribed when symptoms persist despite adequate trial of non-steroidal options.
Dosage and direction
Asthma (Adults): Initial dose typically ranges from 200-400 mcg twice daily, with maintenance doses of 100-400 mcg twice daily. Maximum recommended dose: 1000 mcg/day.
Asthma (Children 5-12 years): 100-200 mcg twice daily, not to exceed 400 mcg/day.
Allergic Rhinitis (Adults): 1-2 sprays (42-84 mcg) per nostril twice daily.
Allergic Rhinitis (Children 6-12 years): 1 spray (42 mcg) per nostril twice daily.
Administration technique is critical: shake inhaler well before use, exhale fully, position mouthpiece correctly, actuate while inhaling slowly and deeply, hold breath for 5-10 seconds. Rinse mouth with water after inhalation to prevent oral candidiasis. Nasal spray requires priming before first use and regular cleaning of applicator.
Precautions
Regular monitoring of growth in pediatric patients is essential due to potential systemic absorption. Patients should be advised that beclomethasone does not provide immediate relief during acute attacks and should not replace rescue inhalers. Caution is warranted in patients with active or quiescent tuberculosis, untreated fungal/bacterial/viral infections, or ocular herpes simplex. Periodic assessments of adrenal function may be necessary during long-term high-dose therapy. Patients should carry steroid identification cards during prolonged treatment.
Contraindications
Hypersensitivity to beclomethasone or any component of the formulation. Primary treatment of status asthmaticus or other acute episodes requiring intensive measures. Active or latent tuberculosis of the respiratory tract. Untreated systemic infections. Recent nasal surgery or trauma (for nasal formulation). Severe nasal septal ulcers (nasal spray).
Possible side effect
Common (>1%): Oropharyngeal candidiasis, hoarseness/dysphonia, throat irritation, cough, headache, nasal irritation/epistaxis (nasal formulation)
Less common (0.1-1%): Adrenal suppression (with high doses), growth retardation in children, reduced bone mineral density, glaucoma/cataracts with prolonged use
Rare (<0.1%): Paradoxical bronchospasm, anaphylaxis, angioedema, psychological effects (agitation, depression)
Drug interaction
Potent CYP3A4 inhibitors (ketoconazole, ritonavir) may increase systemic exposure and adrenal suppression. Concurrent use with other corticosteroids (oral, inhaled, nasal) increases risk of additive effects. Diuretics may enhance hypokalemia potential. Live vaccines should be avoided during high-dose therapy. Beta-blockers may antagonize bronchodilator effects.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next dose. Do not double the dose to make up for a missed one. Maintain regular dosing schedule rather than taking extra medication. Consistent daily use is more important than exact timing for maintenance therapy.
Overdose
Acute overdose is unlikely to cause serious toxicity due to limited systemic absorption. Chronic excessive use may lead to systemic corticosteroid effects including Cushing’s syndrome, adrenal suppression, hyperglycemia, and hypertension. Treatment involves discontinuation and supportive care. Adrenal function should be monitored and may require temporary corticosteroid replacement during withdrawal.
Storage
Store at room temperature (15-30°C/59-86°F) away from light and moisture. Do not puncture, incinerate, or expose to temperatures above 49°C (120°F). Keep canister away from open flame. Nasal spray should be stored with dust cap firmly in place. Discard inhaler after labeled number of actuations has been used, even if it continues to spray.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Individual response to beclomethasone may vary. Always consult with a qualified healthcare professional for proper diagnosis and treatment recommendations. Do not initiate or discontinue medication without medical supervision. Full prescribing information should be reviewed before use.
Reviews
“After struggling with persistent asthma for years, beclomethasone MDI has provided remarkable stability. My exacerbations have reduced from monthly to maybe twice yearly, and I’ve been able to reduce my oral steroid requirements significantly.” - Asthma specialist, 15 years prescribing experience
“The nasal formulation offers excellent control of allergic rhinitis symptoms with minimal systemic effects. Patients appreciate the improved quality of life during allergy season without the sedation associated with antihistamines.” - ENT specialist
“While effective, proper inhaler technique education is crucial. I’ve seen best results when combining medication with spacer devices and regular follow-up to reinforce correct administration.” - Respiratory therapist