Baclosign: Targeted Spasticity Relief for Enhanced Mobility
| Product dosage: 10mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $0.96 | $57.46 (0%) | 🛒 Add to cart |
| 90 | $0.80 | $86.19 $71.57 (17%) | 🛒 Add to cart |
| 120 | $0.73 | $114.92 $87.70 (24%) | 🛒 Add to cart |
| 180 | $0.69 | $172.38 $123.99 (28%) | 🛒 Add to cart |
| 270 | $0.66 | $258.57 $179.43 (31%) | 🛒 Add to cart |
| 360 | $0.62
Best per pill | $344.76 $224.80 (35%) | 🛒 Add to cart |
| Product dosage: 25mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $4.54 | $45.36 (0%) | 🛒 Add to cart |
| 20 | $3.98 | $90.73 $79.64 (12%) | 🛒 Add to cart |
| 30 | $3.19 | $136.09 $95.77 (30%) | 🛒 Add to cart |
| 60 | $3.04 | $272.18 $182.46 (33%) | 🛒 Add to cart |
| 90 | $2.87 | $408.26 $258.06 (37%) | 🛒 Add to cart |
| 120 | $2.71 | $544.35 $325.60 (40%) | 🛒 Add to cart |
| 180 | $2.50 | $816.53 $450.60 (45%) | 🛒 Add to cart |
| 270 | $2.35 | $1224.79 $634.07 (48%) | 🛒 Add to cart |
| 360 | $2.25
Best per pill | $1633.05 $809.47 (50%) | 🛒 Add to cart |
Baclosign (baclofen) is a centrally acting skeletal muscle relaxant specifically formulated for the management of spasticity resulting from multiple sclerosis, spinal cord injuries, and other neurological diseases. It functions as a gamma-aminobutyric acid (GABA) agonist, primarily inhibiting monosynaptic and polysynaptic reflexes at the spinal cord level. This targeted mechanism reduces the frequency and amplitude of muscle spasms, alleviates associated pain, and improves range of motion, thereby facilitating daily activities and therapeutic regimens. Its efficacy is well-documented in clinical settings, making it a cornerstone in the pharmacological management of upper motor neuron syndrome.
Features
- Active Ingredient: Baclofen
- Available Strengths: 10 mg and 25 mg tablets
- Pharmacological Class: GABA-derivative muscle relaxant
- Mechanism of Action: Agonist at GABA-B receptors, suppressing the release of excitatory neurotransmitters
- Onset of Action: Typically observed within 1–2 hours post-administration
- Duration of Effect: Approximately 4–8 hours, dependent on individual metabolism and dosage
- Bioavailability: Approximately 70–85% following oral administration
- Half-life: 3–4 hours in adults with normal renal function
- Excretion: Primarily renal (70–80% unchanged)
Benefits
- Reduces Muscle Hypertonicity: Effectively diminishes increased muscle tone, leading to a significant decrease in rigidity and involuntary contractions.
- Alleviates Pain and Discomfort: Mitigates the pain associated with severe spasms, improving overall patient comfort and quality of life.
- Enhances Functional Mobility: Facilitates improved range of motion, making activities of daily living and physical therapy more manageable.
- Minimizes Spasm Frequency: Lowers the incidence of spontaneous muscle spasms, allowing for uninterrupted rest and sleep.
- Supports Rehabilitation Goals: Aids in the execution of physiotherapeutic interventions by reducing resistance to passive movement.
- Well-Established Safety Profile: Decades of clinical use provide a robust understanding of its pharmacokinetics and adverse effect spectrum.
Common use
Baclosign is predominantly prescribed for the symptomatic treatment of spasticity of voluntary muscle due to pathologies such as multiple sclerosis, spinal cord lesions (including trauma, tumors, or degenerative diseases), and other cerebral origin spasticities, except those of rheumatic origin. It is utilized in both adult and pediatric populations (where appropriate) to manage signs and symptoms including clonus, spasms, and persistent hypertonia. Its use is often integrated into a comprehensive management plan that includes physical therapy and other supportive measures.
Dosage and direction
Dosage must be individualized for each patient based on severity of spasticity and therapeutic response. Therapy should be initiated at a low dosage and gradually titrated upward to achieve optimal effect with minimal side effects.
- Adults: Start with 5 mg orally three times daily. Increase dosage by 5 mg per dose every three days until desired effect is achieved. The average maintenance dose is 40–80 mg daily divided into 3–4 doses. Doses exceeding 80 mg daily should be used with caution and only in severe cases under close supervision.
- Children (over 2 years): Start with 2.5–5 mg orally three or four times daily. May be increased by 5–15 mg daily at weekly intervals. Maintenance dose typically ranges from 20–60 mg daily, not to exceed 60 mg daily unless in severe cases under specialist care.
- Administration: Tablets should be swallowed whole with a glass of water, with or without food. To minimize potential gastrointestinal upset, administration with meals is advisable.
Dosage reduction should be gradual upon discontinuation to avoid withdrawal symptoms, including hallucinations and seizures. Abrupt cessation is contraindicated.
Precautions
- Renal Impairment: Dosage adjustment is necessary in patients with renal insufficiency due to primarily renal excretion.
- Hepatic Function: Use with caution in patients with hepatic impairment; monitor liver function periodically.
- Psychiatric History: Exercise caution in patients with a history of psychiatric disorders, as baclofen can exacerbate conditions such as depression or psychosis.
- Elderly Patients: Increased sensitivity may occur; initiate therapy at the lower end of the dosing range.
- Pregnancy and Lactation: Use only if clearly needed; baclofen crosses the placenta and is excreted in breast milk.
- Operate Machinery: May cause drowsiness or dizziness; patients should avoid driving or operating heavy machinery until response is known.
- Alcohol and CNS Depressants: Concomitant use may enhance sedative effects; avoid or use with extreme caution.
Contraindications
- Hypersensitivity to baclofen or any component of the formulation.
- Patients with a history of peptic ulcer disease (relative contraindication; use with extreme caution).
- Severe psychiatric disorders that may be exacerbated by GABA-ergic agents.
- Acute or chronic renal failure without appropriate dosage adjustment and monitoring.
Possible side effect
Common side effects (≥1%) may include:
- Drowsiness, sedation
- Dizziness, lightheadedness
- Nausea, constipation
- Fatigue, weakness
- Headache
- Insomnia
Less common but serious side effects (<1%) requiring medical attention:
- Hallucinations, confusion, mood changes
- Severe hypotension or bradycardia
- Seizures (particularly upon abrupt withdrawal)
- Respiratory depression
- Rash, urticaria, or signs of hypersensitivity
- Increased liver enzymes
Drug interaction
- CNS Depressants: (e.g., alcohol, benzodiazepines, opioids, sedating antihistamines) — Enhanced sedative effects, risk of respiratory depression.
- Antihypertensives: May potentiate hypotensive effects.
- Levodopa: Possible exacerbation of pre-existing psychiatric conditions or hallucinations.
- MAO Inhibitors: Theoretical risk of increased CNS depression; avoid combination.
- Tricyclic Antidepressants: May increase risk of sedation and anticholinergic effects.
- Lithium: Case reports suggest possible enhanced CNS toxicity.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.
Overdose
Manifestations of overdose may include:
- Severe drowsiness, lightheadedness, coma
- Respiratory depression
- Hypotension or bradycardia
- Seizures (especially in context of abrupt cessation)
- Nausea, vomiting, hypersalivation
Management is primarily supportive and symptomatic. Ensure airway patency, administer intravenous fluids for hypotension, and consider gastric lavage if ingestion was recent. There is no specific antidote. Hemodialysis may be beneficial due to baclofen’s relatively low molecular weight and water solubility.
Storage
Store at room temperature (15–30°C or 59–86°F) in a tightly closed container, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is intended for educational and informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional for diagnosis and individualized treatment recommendations. Do not initiate, adjust, or discontinue any medication without professional supervision.
Reviews
“Baclosign has been instrumental in managing my patient’s spinal cord injury-related spasticity. Titration was straightforward, and the reduction in tone has significantly improved his ability to participate in physiotherapy.” — Neurologist, 12 years experience
“After switching from another muscle relaxant, my patients reported better tolerance and fewer daytime sedative effects with Baclosign, allowing for improved functional outcomes.” — Rehabilitation Specialist
“Effective for reducing nocturnal spasms in MS patients, leading to improved sleep quality and next-day alertness. Requires careful dose escalation to minimize initial drowsiness.” — General Practitioner