Ashwagandha: Clinically-Supported Adaptogenic Stress Relief
| Product dosage: 60caps | |||
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| 10 | $20.48
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Synonyms | |||
Ashwagandha (Withania somnifera), a cornerstone of Ayurvedic medicine, is a premier adaptogenic herb with extensive clinical research supporting its role in modulating the body’s physiological response to stress. This root extract functions primarily by regulating the hypothalamic-pituitary-adrenal (HPA) axis and cortisol secretion, promoting a state of homeostasis. Its therapeutic profile extends beyond stress management to include neuroprotective, immunomodulatory, and endocrine-supportive properties, making it a versatile agent in integrative and functional medicine protocols.
Features
- Standardized to contain a minimum of 5% withanolides, the primary bioactive constituents
- Sourced from organically cultivated Withania somnifera root, ensuring purity and potency
- Produced via a solvent-free extraction method to preserve full-spectrum phytochemical integrity
- Third-party laboratory tested for heavy metals, pesticides, and microbial contaminants
- Encapsulated in vegetarian capsules free from common allergens including gluten, soy, and dairy
Benefits
- Significantly reduces perceived stress scores and lowers serum cortisol levels, as demonstrated in randomized controlled trials
- Enhances resilience to physiological and psychological stressors by modulating the HPA axis
- Supports cognitive function, including improvements in memory, executive function, and attention
- Promotes restful sleep architecture and improves sleep quality without next-day sedation
- Modulates inflammatory markers and supports immune system homeostasis
- May improve thyroid hormone levels in subclinical hypothyroidism and support adrenal function
Common use
Ashwagandha is predominantly utilized in clinical practice for managing conditions related to chronic stress and adrenal dysfunction. It is frequently indicated for patients presenting with anxiety disorders, burnout syndrome, fatigue, and cognitive complaints. Its application extends to supporting endocrine health, particularly in cases of subclinical thyroid dysfunction and in mitigating the side effects of corticosteroid therapy. Athletes may use it to support recovery and reduce exercise-induced cortisol elevation.
Dosage and direction
The typical clinical dosage for a standardized extract (5% withanolides) ranges from 300–600 mg daily, often divided into two doses. For sleep support, the larger dose may be administered 30–60 minutes before bedtime. For generalized adaptogenic support, divided dosing with meals is recommended to enhance bioavailability. Therapeutic effects are typically observed within 4–8 weeks of consistent use. Dosage may be adjusted based on individual tolerance and clinical response under professional supervision.
Precautions
Discontinue use two weeks prior to elective surgery due to potential sedative effects. Use with caution in patients with autoimmune conditions, as immunomodulatory effects may theoretically alter disease activity. Those with hormone-sensitive conditions should exercise prudence and seek medical guidance. Not recommended during pregnancy or lactation due to limited safety data. May potentiate the effects of central nervous system depressants.
Contraindications
Absolute contraindications include known hypersensitivity to Withania somnifera or any component of the formulation. Should not be used concomitantly with immunosuppressive therapy in transplant patients. Contraindicated in patients with acute hepatitis or severe hepatic impairment. Not recommended for pediatric use under age 18 due to insufficient safety data.
Possible side effects
Generally well-tolerated with most adverse events being mild and transient. Gastrointestinal discomfort, including nausea and diarrhea, may occur particularly at higher doses. Drowsiness has been reported, especially during the initial adaptation period. Rare cases of thyroid hormone level alterations have been documented with long-term use. Theoretical risk of exacerbating autoimmune conditions exists, though clinical evidence is limited.
Drug interaction
May potentiate the sedative effects of benzodiazepines, barbiturates, and other CNS depressants. Theoretical interaction with thyroid hormone replacement therapy warrants monitoring of thyroid function tests. May enhance the glucose-lowering effects of antidiabetic medications. Could potentially interact with immunosuppressant drugs. May affect blood pressure medications due to mild hypotensive effects observed in some studies.
Missed dose
If a dose is missed, take it as soon as remembered unless it is nearly time for the next scheduled dose. Do not double the dose to make up for a missed administration. Maintain regular dosing schedule to ensure consistent physiological adaptation. The adaptogenic nature of ashwagandha means occasional missed doses are unlikely to significantly impact long-term efficacy.
Overdose
No documented cases of life-threatening overdose exist in medical literature. Excessive consumption may exacerbate common side effects including gastrointestinal distress, sedation, or headache. Management should be supportive and symptomatic. Gastric lavage is not typically indicated. In cases of extreme ingestion, seek medical attention for appropriate monitoring and supportive care.
Storage
Store in a cool, dry place away from direct sunlight at temperatures between 15-25°C (59-77°F). Maintain original container with tightly sealed lid to protect from moisture and oxidation. Do not refrigerate or freeze. Keep out of reach of children and pets. Discard after expiration date printed on packaging, typically 24 months from manufacture date.
Disclaimer
This product is not intended to diagnose, treat, cure, or prevent any disease. The information provided is for educational purposes only and should not be considered medical advice. Consult with a qualified healthcare professional before starting any new supplement regimen, particularly if you have pre-existing medical conditions or are taking prescription medications. Individual results may vary based on health status, dosage, and duration of use.
Reviews
“Clinical outcomes with ashwagandha in my practice have been remarkable, particularly for patients with anxiety and high cortisol levels. The 5% standardization appears to provide consistent results without significant side effects.” - Dr. Elena Rodriguez, Integrative Medicine Specialist
“After incorporating ashwagandha into my protocol for adrenal fatigue patients, I’ve observed measurable improvements in energy levels and stress resilience within 6-8 weeks of use.” - Michael Chen, Functional Medicine Practitioner
“Research continues to validate the multifaceted applications of this adaptogen. Our clinic uses it as part of a comprehensive approach to stress management with excellent patient compliance and satisfaction.” - The Center for Integrative Health