Alli (orlistat 60 mg) is the only FDA-approved over-the-counter weight loss aid that works physically in the digestive tract to block the absorption of about 25% of dietary fat. Designed for adults with a body mass index (BMI) of 25 or higher, it complements a reduced-calorie, low-fat diet and exercise regimen. By inhibiting gastrointestinal lipases, it prevents the breakdown and absorption of triglycerides, thereby reducing caloric intake and supporting gradual, clinically significant weight loss. This non-systemic mechanism offers a tangible, evidence-based approach to weight management when used as directed under appropriate medical guidance.

Features

• Contains 60 mg of orlistat per capsule, the only FDA-approved OTC weight loss medication
• Non-systemic action: works locally in the gastrointestinal tract without entering the bloodstream
• Blocks approximately 25% of dietary fat absorption when taken with meals containing fat
• Gluten-free formulation, suitable for individuals with celiac disease or gluten sensitivity
• Compatible with a reduced-calorie, low-fat diet and regular physical activity
• Available without a prescription, but intended for use under healthcare provider advisement

Benefits

• Supports clinically meaningful weight loss when combined with lifestyle modifications
• Encourages adherence to a lower-fat dietary pattern by providing immediate physiological feedback
• Reduces overall caloric intake without affecting central appetite regulation or causing stimulant side effects
• May improve cardiometabolic parameters, such as LDL cholesterol and fasting glucose levels, secondary to weight reduction
• Provides a non-habit-forming, pharmacological option for individuals struggling with weight management
• Empowers users to make more conscious nutritional choices through its mechanism of action

Common use

Alli is indicated for weight management in overweight adults (BMI ≥25) as an adjunct to a reduced-calorie, low-fat diet. It is commonly used by individuals who have had difficulty losing weight through diet and exercise alone and seek an evidence-based, non-stimulant aid. Typical users include those with obesity-related comorbidities such as hypertension, dyslipidemia, or prediabetes, under the supervision of a healthcare provider. It is not intended for cosmetic weight loss or use in normal-weight individuals.

Dosage and direction

Take one 60 mg capsule with water immediately before, during, or up to one hour after each main meal that contains fat. Do not exceed three capsules daily. If a meal is missed or contains no fat, omit the dose. A daily multivitamin containing fat-soluble vitamins (A, D, E, K) should be taken once daily at bedtime or at least 2 hours apart from Alli to ensure adequate absorption. Consistent use alongside a nutritionally balanced, reduced-calorie diet and regular physical activity is essential for optimal results.

Precautions

• Not recommended for use during pregnancy or breastfeeding
• Use with caution in patients with history of hyperoxaluria or calcium oxalate nephrolithiasis
• Monitor for signs of fat-soluble vitamin deficiency (e.g., night blindness, coagulopathy) during prolonged use
• Not suitable for individuals with chronic malabsorption syndromes or cholestasis
• May reduce absorption of some lipophilic medications; administer other drugs at least 2 hours before or after Alli
• Discontinue use if severe or persistent gastrointestinal effects occur

Contraindications

• Hypersensitivity to orlistat or any component of the formulation
• Organ transplant recipients receiving cyclosporine therapy
• Patients with reduced gallbladder function or history of biliary disease
• Individuals with anorexia nervosa or bulimia
• Concurrent use with acarbose or other weight loss products
• Pediatric patients under 18 years of age

Possible side effects

Common gastrointestinal effects related to fat malabsorption may include:

• Oily spotting
• Flatus with discharge
• Fecal urgency
• Fatty or oily stools
• Increased defecation
• Abdominal discomfort or pain

These effects are generally mild to moderate, diminish with continued use, and can be mitigated by adhering to a low-fat diet (<30% of total daily calories from fat). Rare but serious side effects may include liver injury, severe or persistent abdominal pain, or symptoms of oxalate nephropathy.

Drug interaction

Alli may reduce the absorption of fat-soluble vitamins and certain medications, including:

• Cyclosporine (contraindicated)
• Warfarin (monitor INR closely)
• Levothyroxine (dose separation required)
• Amiodarone, anticonvulsants (e.g., valproate)
• Oral contraceptives (use additional non-hormonal contraception)
• Antiretroviral protease inhibitors

Administer other medications at least 2 hours before or after Alli dosing. Consult a healthcare provider before combining with other weight loss agents or supplements.

Missed dose

If a dose is missed, resume with the next meal containing fat. Do not double the dose to make up for a missed one. Consistency with meals is important for efficacy, but occasional omission due to fat-free meals or skipped meals will not significantly impact long-term outcomes.

Overdose

Single doses exceeding 60 mg or frequent supratherapeutic dosing may exacerbate gastrointestinal effects such as severe oily stool, abdominal cramping, and diarrhea. There is no specific antidote; treatment is supportive and includes hydration and temporary discontinuation. Medical attention is advised if severe symptoms persist.

Storage

Store at room temperature (20–25°C or 68–77°F) in a dry place. Keep the bottle tightly closed and protect from moisture and light. Do not use if capsules are discolored, damaged, or expired. Keep out of reach of children and pets.

Disclaimer

This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Use only as directed under the guidance of a healthcare professional, particularly if you have underlying medical conditions or are taking other medications. Alli should be part of a comprehensive weight management plan that includes diet, exercise, and behavioral changes.

Reviews

Clinical studies demonstrate that Alli, combined with lifestyle modification, can produce approximately 50% more weight loss than diet and exercise alone over six months. Users report increased dietary awareness and improved eating habits due to the physiologic feedback mechanism. Common user feedback highlights the importance of strict dietary fat control to minimize gastrointestinal side effects. Healthcare providers often recommend it as a short- to medium-term adjunct for motivated patients committed to sustainable lifestyle changes.