Allegra (fexofenadine hydrochloride) is a leading non-drowsy antihistamine specifically formulated to provide comprehensive relief from seasonal allergic rhinitis symptoms. Developed through extensive clinical research, it targets histamine H1-receptors with high selectivity, offering effective symptom control without the sedative effects commonly associated with first-generation antihistamines. Its rapid onset of action and 24-hour efficacy make it a preferred choice among healthcare professionals and patients seeking reliable allergy management.

Features

• Contains fexofenadine hydrochloride 180mg as active ingredient
• Non-drowsy formula with minimal central nervous system penetration
• Rapid onset of action within 1 hour of administration
• 24-hour sustained relief with single daily dosing
• Available in tablet and oral suspension formulations
• Sugar-free and alcohol-free composition
• Compatible with most concomitant medications

Benefits

• Provides complete relief from sneezing, runny nose, and itchy/watery eyes
• Maintains alertness and cognitive function during daytime activities
• Enables uninterrupted sleep by controlling nighttime allergy symptoms
• Supports long-term management of chronic allergic conditions
• Reduces nasal congestion and improves overall respiratory comfort
• Enhances quality of life during high-pollen seasons

Common use

Allegra is primarily indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 6 years of age and older. These symptoms include sneezing, rhinorrhea, itchy nose/palate/throat, itchy/watery/red eyes, and nasal congestion. It is also approved for the treatment of chronic idiopathic urticaria (hives) in patients 6 months and older, providing relief from pruritus and reduction of wheals.

Dosage and direction

For seasonal allergic rhinitis and chronic idiopathic urticaria in adults and children 12 years and older: 180mg once daily. Children 6-11 years: 30mg twice daily. Children 2-5 years: 15mg twice daily (oral suspension). Children 6 months to 2 years: 15mg twice daily (oral suspension). Administer with water on an empty stomach至少 1 hour before or 2 hours after food. Do not take with fruit juices (particularly apple, orange, or grapefruit) as they may reduce absorption.

Precautions

Patients with renal impairment require dosage adjustment (180mg every other day for creatinine clearance <80 mL/min). Elderly patients may be more susceptible to adverse effects. Use caution in patients with cardiovascular conditions, though fexofenadine has shown excellent cardiac safety profile. Pregnant women should use only if clearly needed (Pregnancy Category C). Nursing mothers should consult healthcare provider before use.

Contraindications

Hypersensitivity to fexofenadine hydrochloride or any component of the formulation. Concurrent administration with aluminum and magnesium-containing antacids within 2 hours of dosing. Patients with severe renal impairment (creatinine clearance <30 mL/min) without proper dosage adjustment.

Possible side effects

Most common adverse reactions (≥2%) include headache, drowsiness (uncommon), nausea, dizziness, and fatigue. Rare cases of dysmenorrhea and back pain have been reported. Hypersensitivity reactions including rash, urticaria, and angioedema may occur but are uncommon. No significant ECG changes observed at recommended doses.

Drug interaction

Allegra demonstrates minimal cytochrome P450 metabolism, reducing interaction potential. However, erythromycin and ketoconazole may increase fexofenadine plasma concentrations. Antacids containing aluminum and magnesium reduce absorption and should be administered至少 2 hours apart. Fruit juices may decrease bioavailability and should be avoided near dosing time.

Missed dose

If a dose is missed, take it as soon as remembered unless it is接近 time for the next dose. Do not double the dose to make up for the missed dose. Maintain regular dosing schedule to ensure consistent symptom control.

Overdose

Cases of overdose have reported dizziness, drowsiness, and dry mouth. There is no specific antidote for fexofenadine overdose. Treatment should consist of general supportive measures including gastric lavage if presented within 1 hour of ingestion. Monitor vital signs and provide symptomatic treatment. Hemodialysis does not effectively remove fexofenadine.

Storage

Store at room temperature (20-25°C/68-77°F). Keep in original container with tight closure. Protect from moisture and excessive heat. Keep out of reach of children. Do not use if seal is broken or tablets show signs of deterioration. Discard unused medication properly according to local regulations.

Disclaimer

This information is provided for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new medication. Individual results may vary. Proper diagnosis and treatment recommendations should come from a licensed physician familiar with the patient’s complete medical history.

Reviews

Clinical studies demonstrate Allegra’s efficacy with 70-80% of patients experiencing significant symptom relief within 1 hour of administration. Patient satisfaction surveys indicate 85% preference over previous antihistamine therapies due to its non-sedating properties. Long-term studies confirm maintained efficacy with continuous use throughout allergy seasons. Healthcare providers consistently rate Allegra as a first-line choice for seasonal allergy management based on its safety profile and patient compliance.