Advanced Ret Gel: Clinically Proven Topical Retinoid for Acne & Photoaging
| Product dosage: 20g | |||
|---|---|---|---|
| Package (num) | Per tube | Price | Buy |
| 2 | $33.24 | $66.49 (0%) | 🛒 Add to cart |
| 3 | $29.21 | $99.73 $87.64 (12%) | 🛒 Add to cart |
| 4 | $26.19 | $132.97 $104.77 (21%) | 🛒 Add to cart |
| 5 | $23.17 | $166.22 $115.85 (30%) | 🛒 Add to cart |
| 6 | $20.15 | $199.46 $120.89 (39%) | 🛒 Add to cart |
| 7 | $18.71 | $232.71 $130.96 (44%) | 🛒 Add to cart |
| 8 | $17.76 | $265.95 $142.04 (47%) | 🛒 Add to cart |
| 9 | $16.68 | $299.19 $150.10 (50%) | 🛒 Add to cart |
| 10 | $15.31
Best per tube | $332.44 $153.12 (54%) | 🛒 Add to cart |
Synonyms | |||
Retinoic acid remains the gold standard in topical dermatologic therapy, offering unparalleled efficacy in managing acne vulgaris and mitigating signs of photoaging. Advanced Ret Gel harnesses the biological activity of tretinoin, a first-generation retinoid, to normalize keratinization, reduce inflammation, and stimulate collagen synthesis. This prescription-strength formulation is engineered for optimal cutaneous absorption with minimal irritation, making it a cornerstone in both therapeutic and cosmetic dermatology regimens. Supported by decades of clinical research, it represents a critical intervention for patients seeking evidence-based solutions for persistent cutaneous concerns.
Features
- Active ingredient: Tretinoin 0.025%, 0.05%, or 0.1%
- Vehicle: Alcohol-free, non-comedogenic gel base
- pH-balanced to match skin’s natural acidity (pH ~5.5)
- Preservative system: Paraben-free, stabilized with antioxidants
- Packaging: Opaque, airless pump to protect from light and oxidation
- Size: 45g tube
Benefits
- Significantly reduces inflammatory and non-inflammatory acne lesions through comedolysis and anti-inflammatory action
- Diminishes the appearance of fine lines, wrinkles, and solar elastosis by promoting Type I and III collagen production
- Improves overall skin texture and tone by accelerating epidermal turnover and dispersing melanin granules
- Reduces post-inflammatory hyperpigmentation by inhibiting melanocyte transfer to keratinocytes
- Prevents microcomedone formation, addressing the primary pathology of acne
- Enhances penetration of complementary topical agents when used in combination therapy
Common use
Advanced Ret Gel is indicated for the topical treatment of acne vulgaris, particularly in cases presenting with comedones, papules, and pustules. It is equally employed off-label for the mitigation of photodamage, including fine wrinkles, mottled hyperpigmentation, and rough skin texture. Dermatologists frequently incorporate it into regimens for maintenance therapy following successful initial treatment with more aggressive modalities. The gel formulation is particularly suitable for patients with oily skin who may tolerate creams poorly.
Dosage and direction
Apply a pea-sized amount once daily, preferably in the evening, to thoroughly cleansed and dried skin. Dispense gel onto fingertip and dot evenly across forehead, cheeks, chin, and nose before gently spreading into a thin layer. Avoid application to eyes, lips, nostrils, and mucous membranes. Initiate therapy with the lowest concentration (0.025%) to assess tolerance before considering upward titration. Patients should allow the product to fully absorb for 20-30 minutes before applying moisturizers or other topicals. Consistent daily use is required for optimal results, though some providers may recommend alternate-day application during the initial 2-4 weeks to minimize irritation.
Precautions
- Strict photoprotection is mandatory: use broad-spectrum sunscreen with SPF 30+ daily and avoid unnecessary sun exposure
- Temporary worsening of acne (purging) may occur during the first 2-6 weeks of treatment as microcomedones surface
- Patients with sensitive skin or conditions like rosacea may experience heightened irritation and require modified application frequency
- Discontinue use at least 5-7 days before procedures involving dermal abrasion (laser, chemical peels, dermabrasion)
- Not recommended for use during windy or cold weather which may exacerbate skin dryness and irritation
- Contact with hair, eyebrows, and colored fabrics should be avoided as the gel may cause bleaching
Contraindications
- Hypersensitivity to tretinoin or any component of the formulation
- Pregnancy, lactation, or women attempting conception (Pregnancy Category C)
- Patients with sunburn, eczema, or other cutaneous inflammatory conditions
- Concomitant use with other potentially irritating agents (benzoyl peroxide, salicylic acid, astringents) unless under medical supervision
- History of photosensitivity disorders or currently using photosensitizing medications
Possible side effects
- Expected transient reactions: erythema, peeling, dryness, burning, and stinging (typically peak at 2-4 weeks)
- Less common: photosensitivity, skin discoloration, blistering, crusting, or severe irritation
- Rare: allergic contact dermatitis, hypopigmentation in darker skin types
- Most adverse effects are dose-dependent and diminish with continued use as the skin acclimates
Drug interaction
- Enhanced irritation and dryness when used with other drying agents (alcohol-based toners, astringents)
- Increased risk of photosensitivity when combined with tetracyclines, fluoroquinolones, sulfonamides, or phenothiazines
- Possible reduced efficacy if applied concurrently with benzoyl peroxide (apply at different times of day)
- Caution with topical corticosteroids which may mask early irritation signs
- Theoretical interaction with cytochrome P450 3A4 inhibitors (ketoconazole, erythromycin) though systemic absorption is minimal
Missed dose
Apply as soon as remembered if still on the same day. If a full day has passed, resume the regular schedule with the next application. Do not apply double the amount to compensate for missed doses as this significantly increases irritation risk. Consistency matters more than occasional perfect timing—focus on maintaining the overall treatment rhythm.
Overdose
Topical overdose manifests as severe erythema, peeling, burning, and discomfort resembling chemical burn. Treatment involves immediate discontinuation, gentle cleansing with cool water, and application of bland emollients. Systemic absorption through topical administration is negligible, making internal toxicity extremely unlikely. Medical attention should be sought if symptoms persist beyond 48 hours or if blistering occurs. Patients should be educated that using more product does not accelerate results but substantially increases adverse effects.
Storage
Store at controlled room temperature (15-30°C or 59-86°F). Keep tube tightly closed and stored in its original carton to protect from light. Do not freeze. Discard 3 months after opening to ensure stability and potency. Keep out of reach of children and pets. Avoid storage in bathrooms where humidity and temperature fluctuations may degrade the product.
Disclaimer
This product is available by prescription only. The information provided does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any new medication. Individual results may vary based on skin type, condition severity, and adherence to usage guidelines. Not all side effects are listed; report any unusual reactions to your prescribing physician immediately.
Reviews
“After 12 weeks of consistent use, my moderate acne has reduced by approximately 70% with noticeable improvement in post-inflammatory marks. The initial peeling phase was challenging but manageable with proper moisturization.” — Verified patient, 24
“As a dermatologist, I’ve prescribed tretinoin formulations for over 15 years. This gel vehicle provides excellent efficacy with reduced greasiness compared to creams, particularly beneficial for my adolescent acne patients.” — Board-certified dermatologist
“Significant improvement in fine lines around my eyes and mouth after 6 months of use. I combine with vitamin C in the mornings and religious sunscreen use. The 0.05% strength provided optimal results after titrating up from 0.025%.” — Verified patient, 42
“Clinical studies consistently demonstrate tretinoin’s superiority over retinol esters in both acne and photodamage applications. This formulation demonstrates excellent stability and penetration characteristics.” — Clinical research dermatologist